“a significant trend”

A significant trend of increasing psoriasis ASPR, ASIR and ASDR is observed in all SDI regions from 1990 to 2021.

The Mann-Kendall Test was used to determine if there was a significant trend in articles published by year. 3 Results A total of 9718 unique publications were identified.

The highest solubility was obtained at 130 °C with a 10% ethanol weight as the cosolvent, which is indicative of a significant trend of improvement in omeprazole solubility with the increase in temperature and the use of ethanol cosolvent in various weight percentages.

Quartile-stratified analysis revealed that the highest DI-GM quartile (Q4, ≥ 6) had a 17% lower CVD prevalence than the lowest quartile (Q1, 0–3) (OR = 0.83, 95% CI: 0.72–0.95, p = 0.008), with a significant trend ( p for trend < 0.001).

This finding was also supported by unadjusted analyses of the individual segmentations, which revealed a significant trend toward an increase in the number and total volume of brain contusions with a worse outcome category (Table 3 ).

The 5-year survival of women increased from 52% in 1989 to 59% in 1998 and the 5-year survival of men from 34 to 39% with a significant trend heterogeneity between the sexes [ 4 – 6 ].

Slattery et al (2013) examined the dietary oxidative balance and observed a significant trend toward reduced breast cancer risk with a higher dietary oxidative balance. 18 Xu et al (2025) analyzed US cancer survivors and found that a higher OBS strongly predicted lower all-cause and cancer-specific mortality, 19 suggesting that even after diagnosis, better oxidative balance confers a survival advantage.

The exception was the loop VNS library, which acquired sequences with more negative charge in the second selection step; at present, we do not know if this is a significant trend.

Multivariable analysis confirms a significant trend over time in the use of decurarization, when controlling for other variables, with odds ratio for pharmacological decurarization increasing by 24% (14–34%) in 2017, 47% (36–59%) in 2018, and 59% (47–72%) in 2019, as compared with 2016 ( p < 0.001).

Interestingly, there was a significant trend towards a more flint endosperm (decrease in texture score).

There was a significant trend that the LSM value was higher in patients with HbA1c ≥7% than in those with HbA1c < 7%.

Most of the vegetation types show a significant trend towards earlier snow melt and lower MaxNDVI.

According to the logistic regression analysis, in unadjusted model, compared with participants without any elevated liver enzymes, the OR of diabetes was 1.47 (95% CI: 1.32–1.65) for participants with one elevated liver enzymes, 1.60 (95% CI: 1.36–1.89) for participants with two elevated liver enzymes, and 2.17 (95% CI: 1.69–2.79) for participants with three or four elevated liver enzymes, with a significant trend in OR with increasing number of elevated liver enzymes.

In the present study, we also found a significant trend for the rs13181 allele T → G effect on ERCC2 transcript expression levels in different ethnic populations, indicating that the ERCC2 rs13181 SNP may be a underlying genetic determinant of esophageal cancer risk.

The innovation of exercise-centered lifestyle intervention therapy may become a significant trend in the future.

Statistical analysis One of the methods for estimating the existence of a significant trend is the non-parametric Mann–Kendall rank test, based on the values of individual elements of the series and the position of these elements in the series (Mitchell et al . 1966 ).

Compared to individuals in the lowest TyG-BMI quartile (Q1), the odds of having hypertension diagnosed before age 30 were significantly higher for those in Q2 [OR (95% CI): 3.77 (1.71–8.34)], Q3 [4.14 (1.98–8.65)], and Q4 [10.92 (5.18–23.01)], with a significant trend across quartiles ( P for trend < 0.001).

Figure 14 clearly shows a significant trend in the GRU network’s reconstruction of acceleration data: the data tends to converge towards the mean value of the entire dataset.

The decentralisation of health systems in low and middle income contexts has been a significant trend in health systems reorganisation for forty years.

In multivariable models, no single nursing job type was associated with COPD incidence, although a significant trend toward an increased risk of COPD incidence was observed when classifying jobs according to the level of disinfectant use ( Table 2 ).

In the quarter following easing of restrictions, there was a significant trend towards earlier stage (cStage I/II) disease.

We utilized the proteomic analysis to demonstrate that the reduction of PCSK9 expression in colon cancer cells induced differentially expressed proteins that were mainly enriched in cellular and metabolic processes, while level of MIF expression had a significant trend for decline.

4–6 A well-conducted systematic review has revealed a significant trend: the proportion of patients with poor-grade aSAH undergoing EVT have surged from 10.0% in the 1990–2000 period to an impressive 62.0% between 2010 and 2014.

A larger single-center retrospective cohort study of over 2,700 patients showed that for every age group except patients aged >40 years, there was a significant trend toward higher pregnancy rates with increasing AMH levels.

10 A-B).Under drought stress, the OE lines exhibited superior growth potential compared with the control, and gene-edited lines demonstrated a lower degree of wilting and showed a significant trend in root growth (Fig. 10 C-D).