“a pronounced trend”

Importantly, there was a pronounced trend in favor of letrozole in OS compared with tamoxifen.

As depicted in Figure 1 , the results demonstrate a pronounced trend of increasing fluorescence intensity with prolonged durations of exposure to the antigen (analyte).

aureus incidence density series (per 1000 patient-days) revealed a pronounced trend component that increased from approximately 2.7 per 1000 patient-days at the beginning of the study to a peak of approximately 8.4 in mid-2021, coinciding with the height of COVID-19 hospital activity, before declining to approximately 3.5 by late 2025 ( Figure 7 a–d).

A noteworthy trend emerged where the models exhibited a pronounced trend towards detecting pain in images, surpassing instances of identifying no pain.

As depicted in the above revolution review, electrochemical vibration sensors exhibit a pronounced trend toward structural unification and MEMS-based manufacturing methodologies.

However, a pronounced trend of hypomethylation (Δ methylation > 0.1) in PMDs and a minor shift toward hypomethylation (Δ methylation ≤ 0.1) was found in HMDs for S2 iCCAs, respectively (Supplementary Fig.

Clockwise pressure–temperature evolutionary paths within the Western Granulites show a pronounced trend of isothermal decompression (ITD), which differs from IBC reported for the Eastern Granulites ( Fig. 7 ).

kousa did not exhibit a marked decline under future climate scenarios, its genetic structure displayed a pronounced trend toward homogenization.

But at the same time, it has been shown that patients with pathogenic mutations in the tumor, at the level of a pronounced trend, have shorter overall survival compared with the group of patients in whom mutations with unidentified clinical significance were found (11.1 versus 17.9 months, log-rank test p = 0.07) [ 50 ].

A 2025 report by the Organization for Economic Cooperation and Development (OECD) indicates that healthcare expenditure as a percentage of GDP shows a pronounced trend of rigid growth in most countries.

Isoquercetin and inulin synergistically affect metabolic signalling pathways Western blot analysis revealed a pronounced trend towards increased expression of the GLUT4 receptor in the liver and skeletal muscle of mice fed the HF diet supplemented with combination isoquercetin and inulin (Fig. 3A,B ), which was accompanied by a trend towards increased expression of the insulin receptor in the liver and skeletal muscle (Fig. 3C,D ).

Analysis of TJ proteins revealed that claudin-5 expression in co-cultures was reduced after 24 h of combined HIV-1 NL4-3 infection and METH exposure, with a pronounced trend toward reduction at 48 h, as compared to uninfected controls (Fig. 1 H, I).

At the DNA level, the tail-docked group exhibited a pronounced trend of hypomethylation across multiple functional genomic regions, including promoters, exons, and introns.

Neither set of criteria showed a pronounced trend with onset time.

Nonetheless, there was a pronounced trend for Ca and P supplementation which there was no significant effect on nutrient digestibility.

Moreover, the ImmuCC algorithm applied to RNA-seq data of SPP1-PMN (related to Figure S1J) also predicted a pronounced trend toward increased neutrophils, but not other cells (Figure S4A) [ 32 , 33 ].

In all three SSPs, whether in near-term future or long-term future, there is a pronounced trend of population concentration in urban areas.

Among PIs, a pronounced trend was that boosting with RTV increased the odds of successful treatment.

3 Results 3.1 Reality of health inequality across social classes Univariate analysis of variance results based on five survey waves revealed statistically significant differences in self-rated health across social-class groups, with a pronounced trend toward widening health inequality over time ( Table 2 ).

However, a pronounced trend can be seen in the amplitude of the signal, and this is further emphasised in Fig. 7 , where it is seen that the amplitude of the mean 2D-FT for each hour increases steadily from midnight, peaks at 2 pm and decreases again until 11 pm.

Indeed, in terms of d c the wetting behavior displays a pronounced trend with the interfacial free energy.

Temperature is found to exhibit a pronounced trend with CO 2 conversion as shown in Fig. 3 .

In terms of intrinsic neuronal membrane properties, capacitance (Cm CTR = 35.84 ± 3.050 pF, n = 25; Cm CASPR2 = 44.60 ± 2.723 pF, n = 45; p = 0.0575) and membrane resistance (Rm CTR = 874.9 ± 108.9 MΩ, n = 25; Rm CASPR2 = 725.5 ± 57.01 MΩ, n = 45; p = 0.2231) were not statistically different between conditions, however, there was a pronounced trend for larger capacitance in neurons from CASPR2‐Ab organoids (Figure 1f,g ).

Although the measured time series does not show a pronounced trend, the same running-mean procedure was applied before computing the cospectrum for the field measurements.

42 There was a pronounced trend of increased frequency of negative slopes for H relative to C ( Figure 4 A).