Barely Significant
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“a positive trend”

11,006 sentences · 11,006 papers · 20,836 search hits before verification · confirmed specimen

Sighted at

p=0.09

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

e policies What is new? Across 38 cohort studies (>57 million cumulative participants), adolescent obesity is associated with an immediate and markedly elevated hazard with HRs up to 5.1-7.3 for serious morbidity and up to 27.0-45.3 for T2D before age 25 Hazard of morbidity and mortality showed a positive trend with adolescent obesity severity and time of follow-up, ranging from 2.0 before 30 years to 17.0 before 50 years.
No difference in relapse rate (the primary efficacy endpoint) was observed between treatment arms in the overall patient population; however, a positive trend of improved efficacy (and higher infections) was seen in the subgroup of patients who received rituximab induction therapy followed by belimumab compared to placebo.
Pointwise tests along the z grid with FDR adjustment ( α = 0.05) showed that the proportions of the exposure range reaching statistical significance were: vitamin D 62% (minimum FDR p = 0.0052), vitamin E 54% (0.0036), vitamin B6 32% (1.1 × 10− 5 ), and vitamin C 24% (0.0020); vitamins A and B12 had no significant segments (both 0%; minimum FDR p = 0.255 and 0.884, respectively).The curve shapes indicated nonlinear effects of varying magnitude across vitamins: vitamins D and E displayed overall inverse trends; vitamin B6 showed a positive trend; vitamin C exhibited a weak-to-moderate inverse association primarily over part of its concentration range; and vitamins A and B12 showed no significant effects.
The results obtained from applying fractional integration confirm the information provided by the basic data treatment: on one hand, the overall growth of shale production in the US; and on the other hand, the impact of COVID-19 initially altering the trend direction, only to later return to a positive trend, though with production growth rates lower than those pre-pandemic (Refer to Fig. 1 and Table 2 ) The rationales for such change in the persistence of total shale gas production in the United States are numerous.
Final data from this phase II clinical trial reported a positive trend in mean overall survival (mOS) for patients treated with neoadjuvant GVAX alone (35.0 months compared to 24.8 months in historical controls) in comparison with patients who were additionally treated with cyclophosphamide (mOS 15.4 and 16.5 months) [ 29 ].