“a notable trend”

Across all these datasets, there is a notable trend towards increasing specialization and annotation quality.

Although formal statistical significance was not achieved, likely due to the small sample size of the BRAF/NRAS group, a notable trend was observed between these mutations and histology.

A notable trend was observed in which the drug release rate increased with increasing MCC content.

-epmc yes pmc-license-ref CC BY-NC-ND issue-copyright-statement © BioMed Central Ltd., part of Springer Nature 2025 Introduction Colorectal cancer (CRC) ranks as the third most common cancer globally, and in developing countries, both its incidence and mortality rates are on the rise annually, with a notable trend toward earlier age of onset [ 1 ].

However, regarding age and vestibular function, especially in the patients with CDH23 variants, a notable trend indicated a decrease in the amplitude of cVEMP (Rho = − 0.83) and oVEMP (Rho = − 0.88) with increasing age, showing a stronger correlation than that observed in normal controls (Rho = − 0.33; cVEMP and oVEMP).

There is a notable trend suggesting that F-BRI2 may preferentially interact with highly glycosylated mature Trem2.

6 b illustrates a notable trend that the public displays higher concern for predictive aspects while displaying comparatively diminished concern for the original event.

31 A notable trend identified in the media is for reports of new links between, for example, statins and dementia, or statins and impotence, to be more uncritical than reports of the use of statins in preventing heart disease.

While not all DTC-GT consumers shared their test results with healthcare professionals, there is a notable trend of increasing interactions between DTC-GT consumers and health care professionals.

A notable trend emerges when examining hydroxylation on the B ring (positions 3′, 4′, and 5′).

It was a notable trend toward better survival in patients with lower ERS2 levels in their non-tumor tissue samples, suggesting a possible lower expression/longer survival association.

Upon reviewing the landscape of studies within the domain of ASD and ADHD classification, a notable trend emerges, as illustrated in the summarized literature ( Table 1 ): a predominant focus on binary comparisons between ASD and ADHD, often reliant on survey-based symptomatic datasets, which not alllows clear separation in the cases that have overlapping of symptoms.

7 , there is a notable trend that can be followed; in this case, as the w/c ratio increases, tensile strength increases up until an optimal value of 0.4, wherein it reaches its highest value of 36.95 MPa, and then starts to decrease.

Particularly, uveitis exhibited a notable trend, with its prevalence reaching 50% after 40–50 years post-AxSpA onset (Fig. 1 f).

Interestingly, there is a notable trend of multi-plant formulations devised by semiprofessional herbalists and traditional practitioners.

There was also a notable trend of increased media ALP levels in ejected samples relative to directly plated ones within the same bECM carrier.

Besides significant differences in insurance from the pre-assessment to 1 year follow-up, a notable trend is impact on parents as partners in decision-making for the children’s health.

The line plot for group A reveals a notable trend: while the correlation between these features and AHI is initially strong, it declines rapidly as the timescale increases.

Our analysis revealed a notable trend in the adult population, with the proportion of Type 1 involvement decreasing from 100% in 2010 to 0% in 2024, suggesting a shift in the pattern of cardiac manifestations over time.

A notable trend is the presence of spinal cord bleeding, particularly in older studies from the mid-twentieth century ( Bhimreddy et al., 2023 ; Fletcher et al., 2020a ; Cross et al., 2021 ; Fletcher et al., 2020b ; Xu and O'Reilly, 2018 ; Song et al., 2018b ; Song et al., 2017 ; Payne et al., 2017 ; Fletcher et al., 2021 ; Shimamura et al., 2005 ; Takahashi et al., 2007 ; Ando et al., 2012 ; Ando et al., 2011 ; Oakden et al., 2015 ; Weber-Adrian et al., 2015 ; Song et al., 2023 ).

The DFT validation, while limited to single-point energies without entropic contributions, suggests a notable trend: sampling breadth and energetic favorability may represent independent performance dimensions.

Conclusions These results indicate a notable trend in cervical elongation associated with the use of the LionessTM device, suggesting its potential to enhance cervical support during pregnancy.

Analyzing the trend component of the global time-series data, we discover that only a limited portion of the global sea area exhibits a notable trend in water color ( Fig. 2A , black contours denote confidence intervals at 90% level).

Analysis of the TCGA cohort showed that patients with elevated EGR1 expression exhibited a notable trend toward favorable prognosis, although this trend did not reach statistical significance ( Figure S1 C).

A notable trend was observed in relation to age, with older individuals generally experiencing lower odds of unmet primary healthcare needs.