“a nonsignificant trend”

Effects on Alirocumab (Pharmacokinetics) When comparing alirocumab plus ezetimibe versus alirocumab plus placebo, total alirocumab C max values did not differ statistically (mean [SD] C max , 21.9 [8.9] versus 24.3 [8.6] mg/L; point estimate: 0.92 [90% CI 0.78–1.09]), with a nonsignificant trend toward lower AUC D57–85 in the alirocumab plus ezetimibe treatment group (364 [143] versus 445 [189] mg·day/L; point estimate: 0.85 [0.70–1.03]), suggesting slightly faster clearance of alirocumab in this group.

found no significant difference in leak rates between patients treated with SeamguardTM ( n = 136) and controls ( n = 145), though a nonsignificant trend toward fewer strictures was observed in the SeamguardTM group (four versus ten cases) [ 21 ].

In contrast, patients with mild ARDS (PaO 2 /FiO 2 = 201 to 300) showed a nonsignificant trend towards worse outcomes with higher PEEP; no benefit was seen in the overall population (see Figure 1 ) [ 44 ].

There was a nonsignificant trend toward greater improvement in depression with aromatherapy vs.

Neurosensory retinal sagging was more frequent in the CSC-pattern group ( P = 0.024), while hyperreflective bands and focal RPE defects showed a nonsignificant trend toward higher prevalence in this group.

Of these, 5 reported a significant beneficial effect of 5 different probiotics 33 , 49 , 55 , 82 , 96 (1 of which 33 also showed no significant effect in another study 50 ), 15 (examining 11 different probiotics) reported no significant effect 30 , 36 , 37 , 50 , 57 , 59 , 60 , 61 , 66 , 80 , 83 , 88 , 93 , 94 , 95 (of which 1 reported a nonsignificant trend in favour of probiotics vs placebo), 95 and another reported a negative effect of the specific probiotic treatment. 64 Of the 21 studies, 9 had been published since the original consensus.

Moreover, the continuous terlipressin infusion group exhibited a nonsignificant trend towards lower mortality rates and shorter hospital stays, albeit these differences did not reach statistical significance.

A nonsignificant trend toward better efficacy was observed with faster aspart (estimated treatment difference [ETD] [95% CI] in HbA1c change: –0.14% [–0.40, 0.11]).

The effect of PBT2 on brain MRI volumetrics There was a nonsignificant trend for a slower rate of change in hippocampal atrophy to be slower in the PBT2 group (−0.029 cc/yr) compared to the placebo group (−0.057 cc/yr) over the double-blind phase.

This study also reported significantly lower complication rates in IVIg- versus TPE-treated patients, 17 which was observed as a nonsignificant trend in two other trials. 12 , 18 Specifically, Diener et al. 12 observed comparable rates of clinical AEs, but lower rates of treatment-related AEs with IVIg than TPE treatment.

The intervention group showed a nonsignificant trend toward being more likely to report 0% or 100% consistency of condom use compared to the control group (OR 2.25, 95% CrI 0.84-6.36), and of those, a nonsignificant trend toward being more likely to report 100% condom use consistency compared to the control group (OR 8.03, 95% CrI 0.22-330.31).

Comparison of naive Cre + Rorc flox/flox and CD4‐Cre − Rorc flox/flox mice revealed a nonsignificant trend toward increased abundance of SFB in naive Cre + mice, which is consistent with the previously reported findings in CD4‐Cre + STAT3 flox/flox mice 47 .

The beta for sadness due to vicarious stigma was a nonsignificant trend.

Additionally, potential antiplatelet/antithrombotic effects may also play a potential beneficial mechanistic role for CV risk reduction as noted by a nonsignificant trend in increased bleeding events that was not seen in STRENGTH or OMEMI [51] . 4.

A nonsignificant trend was reached at the aortic root/ascending aorta and the aortic arch in the intraindividual comparison in patients with both MRA acquisitions, which was probably due to the small sample volume.

In mice, the NMDA receptor channel blocker PCP produces a nonsignificant trend toward increased aggressiveness at low doses, whereas it seems to reduce aggression at high (near ataxic) doses ( Belozertseva and Bespalov, 1999 ).

Third, improvement in IU was not significantly associated with any functional outcomes across the sample, though there was a nonsignificant trend linking improvement in IU with better motor functioning.

The association between antihistamine use and incident osteoarthritis supports the findings of mechanistic studies that implicated a number of allergic pathways in the pathogenesis of osteoarthritis: (1) activated and degranulating mast cells are statistically increased in the synovium of patients with osteoarthritis ( 17 ), and there is a nonsignificant trend between the numbers of synovial mast cells and the severity of osteoarthritis ( 18 ); (2) mast cell activation and the release of tryptase mediate synovitis and the breakdown of joint tissue in osteoarthritis ( 17 , 19 , 20 ); and (3) genomic analyses identified associations between interleukin-4 (IL-4) and IL-4 receptor gene polymorphisms and the development of osteoarthritis ( 21 – 24 ).

Avisetron treatment showed a nonsignificant trend towards improvement over placebo in PANSS total scores, PANSS positive subscores, and PANSS general psychopathology scale.

This interpretation seems plausible as both SART and P300 data did show a nonsignificant trend towards worse performance in the premanifest group.

The analysis of severe exacerbations alone showed a similar pattern, with a nonsignificant trend towards increased exacerbations for LABA/ICS in the low eosinophil stratum (HR 1.14 (95% CI 0.88–1.46) but a significant reduction in the high eosinophil stratum with an HR of 0.67 (95% CI 0.48–0.92).

20 , 21 Our analysis did not reveal a statistically significant difference in morphine equivalents administered postoperatively; however, we did see a nonsignificant trend toward reduced morphine equivalents administered on the second POD in the RAKT group.

There was also a nonsignificant trend towards higher in-hospital mortality (12.5% versus 4.9%).

When comparing iCAD and ASCAD, we found a nonsignificant trend in CD4+ T cells’ profile, suggesting that these cells might play a distinct role in the progression of these conditions. 2.3.

Furthermore, findings for nonobese and physically active survivors showed either a nonsignificant trend or significantly lower fatigue scores of a medium effect size (0.28–0.54), apart from 1 study that reported slightly increased fatigue in nonobese subjects (0.04 [−0.33 to 0.41]). 30 Finally, pain was lower in the nonobese groups, with the difference between the nonobese and the obese groups rangin