The rationale for this is based on animal models suggesting that statins can attenuate organ dysfunction by reducing vascular leak and inflammation.[ 84 ] A prospective cohort study in Ireland showed a nonsignificant trend towards lower odds of death in ARDS patients receiving a statin during their ICU admission (OR 0.27, 95% CI 0.06, 1.21; p = 0.09).[ 83 ] However, a recently published retrospective cohort study from the Mayo Clinic (Rochester, MN, USA) showed no difference in mortality or organ dysfunction in ARDS
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For sleep deficits, a nonsignificant trend emerged ( P =.09; d =0.28).
Statistically controlling for the influence of baseline depressive symptoms, mother MDD, Wald = 5.99, p = .01, HR = 1.96 (95% CI = 1.14, 3.37), continued to significantly predict risk for SI during the follow up, but the effect of social support from classmates was reduced to a nonsignificant trend, Wald = 2.84, p = .09, HR = 0.28 (95% CI = 0.06, 1.23).
There was a nonsignificant trend for an increase in total cholesterol immediately after CAP exposure in the OO group (p = 0.09) but not the FO group.
Conversely, no significant changes were noted in diagnostic costs, which exhibited a nonsignificant trend over time ( p = 0.09) despite the overall increase in total costs observed during the analysis.
There was a nonsignificant trend toward reduced postoperative abscess in the post-SP cohort (9.2% versus 3.7%; P = 0.090) (Table 2 ).
Deeks test showed no significant small-study effects in the internal set ( P =.42), while the external set showed a nonsignificant trend toward small-study effects ( P =.09), which should be interpreted with caution (Figure S5a-b in Multimedia Appendix 1 ).
There was a nonsignificant trend in the incidence of online registration of PV signals between both groups (group I: 77.9% vs group II: 71.4%, P = .09).
In the study that found the open approach better, the result was confounded by nerve sparing, so robotic prostatectomies showed a nonsignificant trend toward lower PSM for a non-nerve-sparing approach ( P = .09) [ 10 ].
At 30 min, the initial pooled effect showed a nonsignificant trend favoring the MK group (MD: −0.41; 95% CI: −0.89 to 0.06; P = 0.09) with high heterogeneity ( I 2 =89%) [ Figure 3e ].
Mean achieved METs showed a nonsignificant trend toward lower values in the event group (10.92 ± 3.46 vs. 12.13 ± 2.38, p = 0.09); however, poor functional capacity (METs < 7) was significantly more prevalent among patients with events (15.4% vs. 2.6%, p = 0.022). 3.4.
A nonsignificant trend was also seen in the interval from 8.5 to 24 hours (pop1⁄2 = 38 hr; 95% CI, 17 to −225 hr; p = 0.09).
Side of involvement showed a nonsignificant trend toward a higher proportion of left knees in the damage group (59.02% vs 44.94%; χ2 = 2.868, P = .090).
Among abstracts, there was a nonsignificant trend toward a reduction in the overall percentage of TCSCR abstracts over the time period (r 2 = 0.55, p = 0.09; Figure 1 A ).
In subgroup analyses, adult studies 9 , 20 , 21 , 24 (four studies) showed a nonsignificant trend toward higher risk with long‐acting insulin (RR: 1.41, 95% CI: 0.95–2.10, p = 0.09; I 2 = 0%), whereas paediatric studies 11 , 22 , 25 (three studies) showed no difference (RR: 1.06, 95% CI: 0.68–1.66, p = 0.79; I 2 = 42%).
The predictive value of serum TTR levels was also enhanced in populations with higher percentage of HF patients ( P = 0.009) ( Supplemental Figure 4 ), in cohorts with elevated serum creatinine levels ( P < 0.001) and showed a nonsignificant trend in studies with higher percentage of coronary artery disease patients ( P = 0.09) ( Supplemental Figure 5 ).
There was a nonsignificant trend toward fewer unplanned reinterventions required with FcSEMSs when a DPPS was inserted (OR: 0.50; 95% CI, 0.23-1.10; P = .09; I 2 = 34%).
approached significancep = 0.09
2 , the main effect of drink approached significance ( F [1,21] = 2.98, p = 0.09), such that there was a nonsignificant trend for better global cognitive function following the FR drink relative to the control; however, the planned contrasts were not performed in light of the nonsignificant ANOVA model.
Furthermore, a nonsignificant trend was observed in visual speed in the VR group ( P =.09, Bonferroni P =.02).
Folic acid supplementation was associated a nonsignificant trend toward increased tumor multiplicity (the mean number of mammary tumors per animal) (p = 0.09; Table 4 ) but folic acid supplementation had no significant effect on mammary tumor burden (the sum of all mammary tumor diameters per animal) ( Table 4 ).
Among these older patients, ARBs use was associated with lower mortality (OR 0.52, 95% CI 0.32–0.83, P = 0.006), with ACEIs exhibiting a nonsignificant trend towards a similar effect (OR 0.68, 95% CI 0.43–1.06, P = 0.09).
Glucagon showed a nonsignificant trend toward higher levels in SEMA ( F [2, 29] = 2.547, p = 0.09; Figure 2D ).
More recently, ECPR was compared to CCPR for witnessed, refractory OHCA (i.e., prolonged cardiac arrest and cardiac arrest without ROSC in the field) in a single-center trial that reported a nonsignificant trend towards survival with good neurologic outcome at 180 days (n = 256, 31.5% vs. 22%, p = 0.09) [ 21 ].
Given that in 40% of the sample the Optimal versus Non-Optimal difference was quite small, it is not surprising that the observed difference between the Optimal and Non-Optimal means in the full sample was relatively small; they differed at the level of a nonsignificant trend (mean difference = 1.78; pooled SD = 6.38; t = 1.73, 152, p = .09; d = .28, 95% confidence interval −.04 to .60).
An overall comparison of cytokine profiles (by three-way ANOVA with genotype and treatment as between-subjects factors and cytokine as within-subjects factor) showed a nonsignificant trend towards an effect of poly I:C ( P = 0.09), while there was no effect of genotype ( P = 0.34) and no genotype x treatment interaction ( P = 0.95).