“a nonsignificant trend”

Cilengitide combination treatment showed a nonsignificant trend only in increasing OS in GB patients with unmethylated MGMT promoter, a finding that replicated the failure of Cilengitide to improve OS seen in the CENTRIC trial.[ 202 ] CENTRIC and CORE trials determined that there is no survival advantage for adding anti-αvβ3-αvβ5-integrin therapy (Cilengitide) to SOC for patients with newly diagnosed GB.

18 Subsequently reported 10‐year data, however, showed a nonsignificant trend for better outcomes in both men and women treated with CABG, and significant interaction between sex and revascularization strategy could no longer be detected. 19 In light of such results, sex has been eliminated as a component of the SYNTAX II score, a risk score meant to aid in the decision

10b ), showing a nonsignificant trend to decreased VGLUT1/VGAT ratio after EEdis ( Supplementary Fig. 10b ).

Our data also reveal a nonsignificant trend toward shorter duration of ART in participants within the intermediate and high Ct tertile groups (intermediate and low bacillary loads).

1 are encouraging, but must be read with caution: seropositive patients were also far more likely to receive glucocorticoids; so treatment-selection bias cannot be excluded, and the multivariable model showed only a nonsignificant trend toward higher complete remission.

Basal expression levels of miR‐17‐5p and miR‐19a‐3p in NET cell lines were similar to those obtained in the good prognosis cluster of NENs, whereas a nonsignificant trend was observed towards higher miRNA levels in tumour samples of patients of the poor prognosis cluster (Fig.

In 376 diabetic patients allocated either aspirin or placebo, there was a nonsignificant trend toward benefit for serious vascular events with a rate ratio of 0.88 (95% CI 0.67–1.15) favoring aspirin, but mortality data were not reported for this small subgroup ( 6 ).

In the sciatic functional index, a sensory–motor test, c-Jun OE/+ mice showed a nonsignificant trend toward a transient delay during the second and third week after injury ( Fig. 9 D , E ).

107 Both groups with PPD had significant mood improvement, though there was a nonsignificant trend towards CBT being more effective at six-month follow-up.

In PPMS, a single study reported significantly less patients with EDSS progression in the IVIG-treated group than in the placebo group, with a nonsignificant trend to a delay in time to disease progression ( Pohlau et al., 2007 ).

Dapagliflozin showed the largest reduction in composite renal outcomes, canagliflozin produced the most pronounced reduction in albuminuria, and both dulaglutide 1.5 mg and semaglutide demonstrated significant renal benefits, whereas exenatide showed only a nonsignificant trend.

In addition, there was a nonsignificant trend of larger volume of VA8 in D. moj. sonorensis females compared with males ( Fig. 5M and fig.

3.4.5 Overall appetite On Day 81, there was a nonsignificant trend for mean overall fasting appetite scores to increase compared to Day −1 (corresponding to decreased overall appetite) in the eloralintide‐treated groups, while these scores decreased in the placebo‐treated participants (Table S7 ).

The ZOL group had a nonsignificant trend toward lower fracture rate compared to the control; atraumatic fracture rate was 15 fractures per 100 person-years in ZOL group compared to 29 fractures per 100 person-years in the control ( p = 0.06).

Monthly treatment showed a nonsignificant trend towards better BCVA and reduction in CMT compared to PRN treatment whereas treatment on a PRN protocol required an average of three less injections compared to monthly.

31 However, it reported a significantly higher rate of any intracranial hemorrhage with IVT plus endovascular treatment (OR, 0.82 [95% CI, 0.68–0.99]), whereas our analysis showed a nonsignificant trend toward increased risk with IAT (OR, 1.30 [95% CI, 0.96–1.96]), indicating a potential safety concern that warrants further investigation.

There were no differences in hunger and satiety between obese adolescents with and without BE, albeit there was a nonsignificant trend towards impaired satiety in the BE group.

In the nontobacco modules (PA, eating habits, and weight), there was a nonsignificant trend for messages with exemplars to improve behavioral intentions to engage in the behaviors.

For negative vector eyes, there was a nonsignificant trend for worse aesthetic ratings with negative head tilt ( Figure 8 ).

20 The trial continued over 5 years, and demonstrated sustained benefit of early ART with both experimental arms performing better than deferred ART and a nonsignificant trend toward better outcomes with 96 weeks compared with 40 weeks of ART. 19 The CHAPAS-3 trial in Zambia and Uganda (2010–2014) was another 3-arm trial, powered for a toxicity primary endpoint comparing 3 nucleoside backbones in both ART-naive and virologically suppressed children on stavudine-based first-line ART (Fig. 1 B). 21 Factorial RCT A factorial trial simultaneously allows for 2 (or more) interventions, preferably targeting different aspects of a patient's disease, to be compared with standard treatment(s).

A nonsignificant trend for a higher rate of locoregional involvement in the central compartment and lateral cervical lymph nodes at diagnosis was observed in mPTCc (data not shown).

By contrast, patients with positive ACPA levels showed a nonsignificant trend toward lower disease activity regardless of VIP levels ( Table 3 and Figure 3C ).

Twelve (27%) patients developed transient hypocalcemia and 9 (20%) patients suffered from permanent hypocalcemia, with a nonsignificant trend toward higher incidence with decreasing age.

However, TM2 elicited lower IFN‐γ responses compared to the ORI, and TM1, with a nonsignificant trend toward lower responses relative to TM3.

Alanine injection resulted in a minor increase in the peak concentration of glucagon, while glutamine showed a nonsignificant trend toward increased glucagon secretion.