“a nonsignificant trend”

The risk of graft rejection was significantly associated with conversion in the first posttransplant year (HR 6.60) or the use of anti-CD25 antibody induction (HR 3.71), and there was a nonsignificant trend towards an increase in the risk of rejection in recipients of a deceased donor graft (HR 1.98). 4.

In patients with wild-type BRCA1/2 , there was a nonsignificant trend for a higher response rate with docetaxel.

However, the studies comparing the sulfasalazine/methotrexate combination versus the single agents [ 31 , 32 ] were unable to identify better outcomes for any treatment arm over the others, although there was a nonsignificant trend in favour of combination therapy.

2 Another meta-analysis of 12 studies, including people on peritoneal dialysis, kidney transplant recipients, and people with stage 5 CKD only, reported a nonsignificant trend toward reduction in ischemic stroke with a significant increase in total bleeding risk and no effect on mortality. 39 The association between VKAs and accelerated vascular calcification also warrants careful consideration. 40 Aside from inhibiting VKA-dependent coagulation factors, off-target effects include interfering with vitamin K-dependent inhibitors of vascular arterial media calcification.

Steinhubl et al 40 showed that long-term (one-year) clopidogrel therapy significantly reduced the risk of adverse ischemic events in patients who underwent PCI, albeit with a nonsignificant trend of increased bleeding.

In this study, clinical activity was seen both in PD-L1+ and PD-L1− tumors including similar ORR and PFS and a nonsignificant trend in the 1 L-mn subgroup for longer OS in PD-L1+ tumors.

Our data differ from a recent, randomized controlled trial comparing catheter complications of PICC and CVC in neurocritically ill patients, in which similar outcomes but a nonsignificant trend toward increased complications with PICC placement was reported [ 32 ].

Conclusions In women with obesity we found a nonsignificant trend towards an increased rate of cesarean sections in the group induced with a Foley catheter compared to oral misoprostol; however, the study lacked power for this subgroup analysis.

There was a nonsignificant trend toward those with ICM having a poorer prognosis than those with NICM.

In response to a subsaturating dose of anti-IgM, which triggers BCR, FO B cells from CARD11 +/C49Y mice proliferated significantly better than wild-type or CARD11 C49Y/C49Y FO B cells in a CellTrace Violet dye dilution assay and displayed a nonsignificant trend toward less apoptotic death with a lower percentage of cells staining positive for annexin V and propidium iodide ( Figures 2A – 2C ).

painkillers/anti-depressants/antipsychotics) and in those not in current employment, with a nonsignificant trend observed between rEDS and female gender ( table 1 ).

Participants 3 and 8 showed a nonsignificant trend to rely on a specifying variable.

In the high-sodium group, cumulative syndecan-1 shedding showed a nonsignificant trend toward being higher than in the control and low-sodium groups.

Similarly, the mLN showed a nonsignificant trend towards increased production of IL-10 by B cells in IMQ-treated P. distasonis -gavaged WT mice in comparison to IMQ-treated PBS-gavaged WT mice ( Supplementary Figure S6G ).

However, glucagon-stimulated phosphorylation of CREB at Ser133, pCREB S133 , was significantly reduced in RACK1 fl/fl mice injected with AAV8-TBG-iCre compared with AAV8-TBG-GFP, whereas basal CREB phosphorylation showed a nonsignificant trend toward reduction ( Figure 3 B ).

At the 36-month follow-up, there were no significant differences regarding use of medication apart from a higher proportion of intervention patients receiving calcium channel blockers, although there was a nonsignificant trend towards higher use of statins, diuretics, and angiotensin receptor blockers.

A similar difference is also observed between words and syllables in the Turkish dataset, and a nonsignificant trend for Dutch and Mandarin speaking participants when they were listening to their native languages.

showed a similar functional outcome for PFA compared to TKA, a nonsignificant trend to lower satisfaction for TKA, and a shorter length of stay for PFA in a matched retrospective study [ 52 ].

Interestingly, although measured salivary cortisol and cortisone levels are free (nonbound) levels, one study in healthy volunteers showed a nonsignificant trend of higher salivary cortisol and cortisone levels in women with higher estrogen levels (pregnant women or those taking oral contraceptives) [ 4 ].

It is notable that patients treated with either tramadol or methadone showed a nonsignificant trend for a better outcome than those treated with other opioids, even with an equivalent morphine dose for both groups, suggesting that the different mechanisms of action for these two agents may have clinical implications requiring further study.

The intervention did not significantly reduce retinopathy of prematurity, although a nonsignificant trend toward lower severe BPD was reported ( Ley et al., 2019 ).

There was also a nonsignificant trend suggesting a higher probability of DTG/3TC initiation in individuals with dyslipidemia or hypertension.

Men and women in the VDD group showed a nonsignificant trend toward lower dietary vitamin D intake than those without the deficiency.

Additional subgroup analyses revealed a nonsignificant trend for a lower cumulative rate of recurrent CDI in participants with hematologic malignancy or solid tumor.

There was a nonsignificant trend to a longer stay in the ICU or IMC in patients without secondary skin closure, which might be due to the higher ASA stage found in this patient group.