“a nonsignificant trend”

The OCT grades, although not significantly different overall ( P = 0.07), showed a nonsignificant trend with RPGRIP1, most often Grade 2 (focal EZ interruption; 8/12, 66.7%), whereas PDE6C included relatively more advanced grades (e.g., Grade 5 with outer retinal atrophy with RPE loss; 4/15, 26.7%).

However, there was a nonsignificant trend towards greater improvements in quality of life and depression symptoms in the intervention group than in the control group that might be confirmed if we had the larger sample size and longer follow-up period.

Efflux pump CDR1 was upregulated and a nonsignificant trend toward increased biofilm formation was noted.

In an initial RCT in Wuhan, remdesivir use showed a nonsignificant trend toward reduced time to clinical improvement. 72 However, this trial did not reach its target enrollment because of marked reductions in new patient presentations.

6 A ) and a nonsignificant trend toward increased levels of LAMP2a ( Fig. 6 B ).

However, there was a nonsignificant trend toward retention of or switch to the mesenchymal subtype at recurrence across bulk/EN regions, consistent with other studies, 44 and suggesting some selection for this subtype with treatment. 29 , 39 While spatial dynamics have been less well studied, intratumoral transcriptional subtype heterogeneity has been previously demonstrated. 39 Our data revealed a significant switch toward a proneural subtype among NE regions as compared to bulk/EN.

11 A second trial involving patients with metastatic disease found a nonsignificant trend toward cumulative increases in osteonecrosis of the jaw (1% in year 1 and 2% in year 2). 12 The majority of patients who developed osteonecrosis of the jaw (79%) had poor oral hygiene, dental appliances, and/or a recent history of tooth extraction.

45 , 46 , 47 However, further definitive studies have since had inconsistent results and recent meta-analyses of multiple trials demonstrate only a nonsignificant trend towards benefit in patients treated with NAC.

There was a nonsignificant trend toward increased use of palliative regimens using 8 Gy in 1 fraction or 20 Gy in 5 fractions with IROC; there was no difference before or after IROC implementation in delivery of stereotactic body radiation therapy (SBRT) and/or stereotactic radiosurgery (SRS) regimens in the inpatient setting ( Table 1 ).

These findings are similar to those in a study of an elderly population in Finland where detection of pneumococcus was significantly reduced for NP culture and showed a nonsignificant trend toward reduction by PCR [ 22 ].

In our first study on ovarian cancer [ 52 ], we observed a nonsignificant trend for a higher HR of HGSOC related to a VEF above as compared to below median level, but this was not confirmed in our subsequent WHI study [ 68 ].

Therefore, ICE guidance allowed for more complete and effective substrate modification within a similarly safe dosage range, as evidenced by significantly larger LVAs achieved despite a nonsignificant trend toward higher ethanol consumption volume.

Results observed by the International Collaboration of Epidemiological Studies of Cervical Cancer indicated a nonsignificant trend for CIN 3 and an increasing number of childbirths; however, the risk of CIN 3 only increased with the number of full-term pregnancies (RR for ≥7 births vs. nulliparous women after adjustment for the lifetime number of sexual partners and age at first sexual intercourse, 1.60).

Smoking ( 33 , 46 , 61 , 81 ) showed a nonsignificant trend toward higher PC diagnosis (OR: 1.49, CI: 0.61–3.63; I 2 = 74%, CI: 27%–91%) (see Supplementary Figure S10, http://links.lww.com/CTG/B403 ).

There was a negative effect of temperature late in the season (3.0% decline in hunter effort with 1°C decrease in temperature), but no effect mid-season and a nonsignificant trend toward a positive effect in the beginning (1.3% increase in hunter effort with 1°C in temperature).

Compared with the sPLC post condition, the cPLC post condition showed a nonsignificant trend towards enhanced facilitation and decreased inhibition ( Figure 3d ).

A nonsignificant trend of FoxP3 + cell induction was also observed upon niraparib treatment (Fig. 2D ), suggesting the promotion of overall immune cell infiltration, including regulatory T cell infiltration, in this model.

It was not powered to look at patient-centered or patient-level effects such as mortality or other health outcomes, but many of the secondary outcomes showed a nonsignificant trend toward benefit for propranolol.

The CyclinD1 CKO mice had a nonsignificant trend toward increased STAT3 expression and activation ( Supplemental Figure 4 ), and the exact mechanism of exacerbated tubular injury is beyond the scope of this study.

On the other hand, tocilizumab has demonstrated efficacy in the treatment of acute GVHD ( 40 ), and, in a phase III trial, showed a nonsignificant trend toward lower incidence of grade II-IV aGVHD In the HLA-matched unrelated donor transplant setting ( 41 ).

Crucially, pairwise comparisons between mind states revealed different behavioral profiles for MW and MB: While both were characterized by more FA and misses than during ON, FA were equally frequent during MW and MB (with a nonsignificant trend for more FA during MW trials) and misses were more frequent during MB (i.e.

Although liver weights showed a nonsignificant trend toward reduction with PGE treatment ( Figure 6 A), histological analysis demonstrated clear improvements in hepatic steatosis in the PGE-treated groups ( Supplementary Figure S3B ).

18 In a prospective study evaluating 1600 patients from 12 European counties undergoing total hip or knee surgery wherein all patients were screened for FVL mutations and prothrombin gene mutations, the investigators found a nonsignificant trend toward increased risk of VTE in FVL patients. 17 These studies from other surgical specialties generally conclude that the best course of action to protect these patients from VTE includes a robust screening and perioperative anticoagulation protocol, with consultation of hematology if appropriate.

19 Moreover, the application of SVF for rodent models with thin endometrium showed a nonsignificant trend for improvement in endometrial area or gland density. 20 However, powerful evidence to demonstrate the effectiveness of SVF in treating patients with thin endometrium is still insufficient.

There was a nonsignificant trend toward a reduced incidence of invasive aspergillosis, although the absolute number of events was remarkably low in both arms (n=1 micafungin; n=7 fluconazole), possibly due to the inclusion of a large proportion of low-risk patients (70% autologous HSCT).