“a marked trend”

We observed a marked trend of development of apps oriented toward the Android platform (63%), which can be associated with the popularity and assortment of mobile devices (cell phones and tablets) for this platform.

The believe in an effective treatment of schizophrenia has increased significantly and there was a marked trend towards preference of medication over psychotherapy.

Like Cho et al., they detected a marked trend towards a decreased risk of acute GVHD in recipients with AA genotype (low VDR activity).

A marked trend was observed with an increased proportion of delayed reconstructions undertaken over time.

Starting with the ABTS assay ( Figure 3 a), a marked trend of decreasing AOX was observed from the oral to the intestinal phase, with values in T1 and T3 being very close to zero.

However, besides the expected unlimited freedom to rotate of CAN in solution, there is a marked trend to select values between 60° and 80°.

Finally, there was a marked trend towards the administration of drugs capable of rapidly and effectively increasing bone mineral density at an early stage of treatment.

According to the 2024 Report on Adolescent Mental Health and Academic Status published by the Chinese Academy of Sciences, the screening rates for depression, anxiety, and other emotional disorders have exceeded 25%, indicating a marked trend toward earlier onset, greater severity, and increased complexity.

Interestingly, a marked trend of a higher colony number in soft agar in CD70-positive (CD70 + ) cells compared to CD70-negative (CD70 – ) was identified in 9 ovarian, 5 lung, 2 kidney and 2 brain cancer cell lines in soft agar assays (Table 1 ).

Despite a marked trend, the Post hoc LSD test does not prove statistically significant difference between any of the resolution.

After 6 weeks of dosing, we found that PTC-041 did not alter the robust increase in total α-synuclein observed, but it induced a marked trend towards reduction in aggregated and phosphorylated α-synuclein ( Fig 8A and 8B ). •To evaluate the effect of PTC-041 on neuronal viability in older mice, a separate study was conducted wherein 6-week-old transgenic Line 61 mice were dosed with PTC-041 daily for 15 weeks.

The number of articles focusing on thymol has exhibited a marked trend, surging from just over 100 in 2001 to over 1,000 in 2024 ( Figure 2A ), with the majority of this research originating from the United States, Iran, and China ( Figure 2C ).

Although we expected a similar variation in our survey on the forest sector, we did not find such a marked trend, and the views on the existence of climate change and its causes were consistently similar across the studied provinces (see S3 File ).

There was a marked trend towards the lower limit of the target range in the standard-dose group and towards the upper level limit in the reduced-dose group ( Figure 1 ).

There has also been a marked trend towards the replacement of lupin cropping by canola, with the WA lupin area declining gradually from 1 million ha in 2000 to 400,000 ha in 2022 [ 158 , 159 , 160 ].

There is a marked trend in the widely read newspapers of publishing positive news on smartphone use by teenagers in December; but most of them published the negative effects of the device in September. 7.

Furthermore, we found methylation to be significantly correlated with PFS and a marked trend towards higher mean methylation levels in non-responding tumors in comparison to tumors responding to anti-PD-1 therapy (UHB ICB cohort).

From the exploratory variables included in the univariate analysis, only hormone receptors had a significant influence on DFS (HR: 1.683, 95% CI: 1.056–2.683, P =0.029), whereas the type of treatment had a marked trend but not statistically significant (HR: 1.591, 95% CI: 0.990–2.556, P =0.055).

However, the statistical analysis of the results still indicate that MV repair may play an important role in the elderly, because there was a marked trend for better long-term clinical outcomes.

Our analysis revealed a strong association between high USP15 expression and advanced disease stages, showing a marked trend with M stage and a statistically significant association with tumor–node–metastasis (TNM) stage (p<0.05) ( Table 1 ).

The direct analysis of the temporal dynamics of Mo and Cu did not allow us to identify a marked trend of variation.

These cross-validated classification methods show that cortical activation has significantly changed for Skilled trainees during the posttest when compared to Skilled trainees on the pretest or untrained Control subjects, whereas Unskilled trainees do not exhibit such a marked trend.

There is a marked trend in mortality according to the referral type—urgently referred, non-urgently referred and not referred—suggesting risk stratification by the GP.

In particular, in the age group over 60 years, the authors identified a marked trend reversal with rising suicide rates.

Under these circumstances, one can use hygroscopic metal salts (often hydrated salts) with a marked trend to capture water when mixed with organic anions, in such a way that the mixture, once sealed and subject to heat, may possess enough solvent as to completely mix the reagents and promote the crystallization aided by the autogenous pressure generated in the vessel.