“a marked trend”

In the UKB cohort, we observed a marked trend between the lowest quartile (n = 522) and the highest quartile (n = 735).

Muscle mass and PCSA showed a marked trend towards positive allometry (26 and 27 out of 34 muscles respectively) and fascicle length showed a more mixed scaling pattern.

Thus, if a marked trend can be observed toward an increase in hot day events (Eq. 2.7), the observed data remain insufficient to draw strict conclusions related to the path of change.

Although total annual rainfall does not show statistically significant trends throughout the 20th century, the analysis of seasonal rainfall reveals a marked trend to the decrease of spring rainfall during the 20th century in the southwest of Spain.

While, as expected given the evolutionary heterogeneity of the disease, no statistically significant results were found, the graphs reflect a marked trend toward increased lymph node involvement the longer the time to surgery, both globally and in certain biological subgroups, such as poorly differentiated tumors (G3).

However, the excess mortality from 1996 to 1998 has changed to a marked trend of lower mortality in 2005–2008, which cannot solely be attributed to the drop in child mortality, and our data suggest that this is partly due to the introduction of IPT.

This increase showed a marked trend in types such as ostomy, hearing, and physical disabilities.

By contrast, while showing a marked trend in favor of icatibant in the US (FAST-1) trial, the difference between icatibant and placebo did not reach significance for several endpoints, including the primary end point. 40 This is likely to result from underpowering, since the low numbers were randomized for a treatment where delayed and variable responses are expected, and where the outcome measures are subjective.

On the other hand, aberrant and autistic behaviors follow a marked trend of aggravation from around the age of 18.

We observed a marked trend towards increased expression of total ezrin and phospho-ezrin in resistant melanoma cells under baseline conditions, which indicates that increased abundance of ezrin could be potentially linked with the vemurafenib-resistant phenotype in BRAFV600E-mutated melanoma cells. 2.6.

Increased levels of all kinds of phospholipids, lysophospholipids, plasmalogens and ceramides, with the exception of lactosylceramide, was a marked trend in siRNA-Prdx6 treated cells.

Previous studies showed that DS patients exhibit a marked trend in developing overweight and obesity, mostly as a result of a lower resting metabolic rate, a higher consumption of energy-rich foods, and a poor physical activity.

Crystallographic structures All of the buffers exhibit a marked trend of p K a decrease in Table 1 , with the exception of the 2-hydroxypiperazine series ( 2 , HEPES, and EPPS).

Additionally, there has been a marked trend towards a younger age group for this disease in recent years and Significant increase in the incidence of colorectal cancer before the age of 50 years, especially in countries with high socio-demographic populations ( Dekker et al., 2019 ; GBD, 2019 Colorectal Cancer Collaborators, 2022 ; Sinicrope, 2022 ).

A marked trend of seasonal displacement in permafrost areas was detected using MT-InSAR and the interannual displacement increased yearly.

Consequently, we can conclude that with the continuous progress and development of DIG, the value of the older adults care industry exhibits a marked trend of growth.

Moreover, the small sample, which did not even contain all types of B3 lesions, made it difficult to obtain statistically significant results, especially in the analysis of histological types of B3 lesions, where we observed a marked trend toward upgrade in ADH lesions.

While there is a marked trend of increases in wind speed as mslp decreases below 1,000 hPa in the tropics, in the extratropics, the relationship between mslp and wind speed is much less pronounced, such that it is not uncommon to have low wind speeds when the mslp is low.

Table 2 shows that the modularity index of the GIOTN underwent phased changes from 2000 to 2023: it rose gradually from 0.30 in 2000–2006 to 0.49, indicating strengthened intra‐community ties and weakened inter‐community links, with early signs of regional clustering; declined progressively to 0.06 in 2006–2014, reflecting enhanced inter‐community connectivity and greater trade network integration; peaked at 0.50 in 2015, when the network split into multiple highly autonomous trade communities, underscoring a marked trend toward regional cooperation; fell back to 0.08 in 2015–2020 as inter‐community links intensified and the network reintegrated, demonstrating the resilience of globalization; and rose again in 2021–2023, signaling stronger intra‐regional cluster connectivity in the post‐pandemic era and the reemergence of regional cooperation as a dominant feature.

The analysis of HIV/AIDS misconceptions indicated a marked trend: approximately one-third (33.3%) of the 2022 participants regarded “HIV as a filthy disease,” up from 25.4% in 2012, which was a significant increase (OR year = 1.04, p < 0.001).

Assessments grounded in cognitive and neurophysiological methodologies reveal that executive function, though initially emerging during the foundational years of life, exhibits a marked trend of continual strengthening and maturation throughout childhood and adolescence [ 50 ].

Comparison of the gene expression of mTEC 3–10 and cTEC 1–2 cells showed a marked trend toward higher levels of expression of DDR genes in mTEC 3–10 cells compared to cTEC 1–2.

The study by Revol [ 88 ] evidences a marked trend to anxiety disorders in a population of early developers consulting in child psychiatry, observing phobias, and even obsessive-compulsive disorders. 5.

Its association with increased resuscitation volume, use of vassopresors and BSA, however not being statistically significant, shows a marked trend that a major sample size probably would strengthen.

In the present study we now demonstrate that hypothalamic Y2 receptor deletion in adult mice results in sustained positive energy balance characterized by hyperphagia, increased body weight gain and a marked trend towards increased fat accretion in white adipose tissue.