Barely Significant
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“a favorable trend”

1,336 sentences · 1,336 papers · 2,253 search hits before verification · confirmed specimen

Sighted at

p=0.09

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

34 In the TAKT study (Takayasu Arteritis Treated With Tocilizumab), a double-blind phase 3 RCT, there was a favorable trend toward tocilizumab over placebo for time to relapse, the primary end point; the relapse rate was higher in the placebo arm (53% versus 23%). 22 In the longer open-label follow-up in which all patients received tocilizumab for 96 weeks, disease stabilization was observed in 70% and improvement was seen in 20%. 35 One challenge is that routinely measured acute-phase reactants become unreliable indicators of disease flare in patients receiving tocilizumab.
The lack of significant improvement in mortality rates due to falls in the Polish elderly population observed since 2009, despite a favorable trend in the first decade of the analysis, may be related to an increase in the dynamics of growth in the trend of the oldest people (i.e., those aged over 80), particularly noticeable in the last decade (from 6.4% to 8.5%).
Although the proportion of patients from the BRV group who entered into the open phase of the individual trials did not generally show a favorable trend compared to the placebo group, a meta-analysis of trials of adjunctive AEDs in adults with drug-resistant focal epilepsy found the responder rates to placebo virtually double between 1989 and 2009. 100 This may partially explain the unnoticeable difference between BRV and placebo groups.