110 , 114–117 However, it should be noted, however, that, in a retrospective study of ovarian cancer patients treated with olaparib, there was a positive trend between high SLFN11 expression and better PFS, although this was not observed when overall survival was considered. 118 Olaparib and other PARPi are able to exert anticancer activity not only because of their ability to inhibit the enzymatic activity of PARP but also because they trap PARP into DNA.
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The sentences
Although the interim OS analysis was not statistically significant in the ITT population, a favorable trend in overall survival was also observed in the BRCA wild-type, HRD-positive population.