“a decreasing trend”

Bax and c-Caspase3 expression were increased, while Bcl2 expression showed a decreasing trend ( p < 0.05) ( Figure 4 I).

The model group exhibited significantly elevated BUN and 24h-UTP compared to controls (both P < 0.01), while both QRYSXZF and dapagliflozin treatment groups showed markedly reduced BUN and Cys-C levels versus model animals (P < 0.01), with 24h-UTP demonstrating a decreasing trend that did not reach statistical significance (P > 0.05).

The levels of IFN‐γ, TNF‐α, and CXCL10 also showed a decreasing trend in the high‐dose group ( p < 0.05) (Figure 3e ).

A decreasing trend in viable cell counts due to concentration differences was also observed up to the final 3 h of incubation ( Fig. 6C and F ) ( P < 0.05).

Notably, serum ATIC levels in patients with MM exhibited a decreasing trend as the treatment response improved, and the Remission Group showed a marked decrease compared to the Active Disease Group (p < 0.05).

TOS values differed significantly ( p < 0.05) between different time intervals in all test groups with increase in values upto day 7, followed by a decreasing trend afterwards, except for a non-significant ( p ≥ 0.05) decrease in Group 3 and 4 on day 28.

When comparing different ages within the same pig breed, the plasma ALP level of all pig breeds showed a decreasing trend with age ( p < 0.05).

RI values in both groups increased from T1 to T4 compared with T0 but presented a decreasing trend over time; RI values in Group M were significantly lower than those in Group C at all postoperative intervals ( p < 0.05).

Changes in CT in the SMILE group CT-C, CT-N1, CT-N2, CT-S1, CT-S2, CT-I1 and CT-I2 were significantly increased at 1 week postoperatively compared with their preoperative levels (P<0.001), followed by a decreasing trend and the return to preoperative thickness by 3 months after surgery (P>0.05).

We then determined the time series of β SOT using 15-year moving windows from 1982 to 2021 at each pixel and found that 38.6% of regions exhibited a significant increase in β SOT for kNDVI, while 22.0% showed a decreasing trend ( p < 0.05) (Fig. 1A ).

thetaiotaomicron exhibited a decreasing trend ( P > 0.05, Supplementary Fig. 9B ), negatively correlated with depression severity ( r = − 0.7199, P < 0.01, Supplementary Fig. 9D ) and Th17 cell percentages ( r = − 0.6800, P < 0.05, Supplementary Fig. 9E ).

Following 2 h of LXA4 treatment in infected cells, TNF-α mRNA expression exhibited no statistically significant reduction, although a decreasing trend was observed ( p > 0.05).

There was a decreasing trend in the HR within the ADL subgroups of widowed centenarians (all p > 0.05).

After 6 weeks of intervention, EG showed a decreasing trend in both WA% and Pi10 across all GOLD grades, with the most notable improvement observed in GOLD II–III patients ( P < 0.05), suggesting initial amelioration of airway remodeling.

Compared with the Control group, AFB1-induced liver injury resulted in a significant increase in MDA content in liver homogenate, no significant change but a decreasing trend in GSH ( p < 0.05), and a significant decrease in T-AOC ( p < 0.05), indicating that AFB1 induced hepatic oxidative stress, leading to decreased total antioxidant capacity and increased lipid peroxidation.

Among saturated fatty acids, short- and medium-chain fatty acids (C10:0, C12:0, and C14:0) showed a decreasing trend with increasing replacement level ( p < 0.05), while palmitic acid (C16:0) remained relatively stable ( p > 0.05).

Although a decreasing trend was observed, the level of p-AMPKα−1/AMPKα−1 did not reveal a statistically remarkable difference between the two groups ( P > 0.05).

Although a decreasing trend in cyst burden was observed in MYR-treated mice compared to controls, the difference did not reach statistical significance ( p > 0.05).

In contrast, among women, a decreasing trend in DR prevalence was observed with increasing TT concentrations (tertile 1: 48.9%; tertile 2: 44.4%; tertile 3: 25.0%; P < 0.05).

(3) Compared with preoperative levels, both groups showed a decreasing trend in SOD and NSE and an increasing trend in NGF and BDNF after surgery, with the observation group showing more significant and sustained changes over time (P < 0.05).

Compared with model group, the protein expression of NLRP3, Pro-caspase-1, IL-1β, and IL-18 in AS-IV-L, AS-IV-M, and AS-IV-H group significantly decreased ( p < 0.05), while there was a decreasing trend of the protein expression of Cleaved-Caspase-1 without statistical significance ( p > 0.05).

In contrast, the SND group exhibited a significant increase in the relative abundance of Lactobacillus ( P < 0.05), an increasing trend in Faecalibacterium , and a decreasing trend in Cupriavidus , without statistical significance ( P > 0.05).

Although PNI levels showed a decreasing trend in the high-titer group, the difference was not statistically significant (P > 0.05). 3.2 Comparison of PNI, CD4 + /CD8 + ratio, and 25(OH)D levels in SLE patients stratified by anti-dsDNA titer As shown in Figure 2 , PNI, the CD4 + /CD8 + ratio, and 25(OH)D differed significantly among the three groups.

A total of 10 ARGs types exhibited a decreasing trend, among which 6 ARGs types were significantly decreased, including beta-lactam ( P < 0.05, R 2 = 0.61), MLS ( P < 0.05, R 2 = 0.53), quinolone ( P < 0.01, R 2 = 0.84) and tetracycline ( P < 0.05, R 2 = 0.64) (Fig. 5a ).

Although there was a decreasing trend in the relative abundance of norank_f__Muribaculaceae in the IF group, this difference did not reach statistical significance ( p > 0.05).