“a decreasing trend”

Through trend test analysis, the clozapine serum concentration showed an increasing trend with increasing drug dose ( p < 0.001), and the C/D ratio showed a decreasing trend with increasing daily drug dose ( p < 0.001) (Table 3 ).

A decreasing trend in current smoking habits in each quantile of the 1996–2000 year (adjusted OR: 0.82, 95% CI: 0.71–0.93, P = 0.001), 2001–2005 year (adjusted OR: 0.70, 95% CI: 0.62–0.80, P = 0.001), 2006–2010 year (adjusted OR: 0.75, 95% CI: 0.67–0.84, P = 0.001), 2011–2015 year (adjusted OR: 0.48, 95% CI: 0.42–0.54, P = 0.001), 2016–2020 year (adjusted OR: 0.48, 95% CI: 0.43–0.54, P = 0.001), and ≥2021 year (adjusted OR: 0.46, 95% CI: 0.40–0.53, P = 0.001) was observed in comparison to the quantile 1991–1995 year.

The number of memory lymphocytes was increased in all subgroups of patients, except for dying patients that showed a decreasing trend (mild: basal median 477 (range 192–718), 1 week median 618 (range 425–806) p < 0.001; moderate: basal median 354 (range 202–564), 1 week median 474 (range 346–651) p < 0.0001; severe: basal median 350 (range 214–509), 1 week median 534 (range 306–767) p = 0.02; died: basal median 333 (range 161–683), 1 week median 281 (range 130–534).

The results remained consistent, with significant differences in mean age, PAASI and AKs, all showing a decreasing trend with increasing MN count ( p < 0.001), while PLR increased ( p = 0.01).

Normal delivery The ratio of normal vaginal deliveries showed a decreasing trend during the study years (unadjusted b=−0.94, p<0.001; adjusted b=−0.81, p=0.026), as well as before and after the intervention (unadjusted b=−7.41, p=0.008; adjusted b=−7.07, p=0.006).

Drivers testing above the legal breath alcohol concentration limit showed a decreasing trend, from 4.1% (95% CI 2.9% to 5.5%) at baseline to 0.6% (95% CI 0.2% to 1.2%) in the end of 2018 (p<0.001); however, more than half of drivers refused breath tests at checkpoints despite steep legal penalties.

Although there was a decreasing trend (p<0.001) over the years in the mean LoS (5.0 ± 1.7 days in 2005 vs. 4.4 ± 1.7 days in 2015) and in the percentage of LoS > ED (58.2% in 2005 vs. 27.9% in 2015), the variability among the 12 maternity centres was considerable.

As shown in Figure 4 a,f, Bcl-2 showed a decreasing trend after 6b administration, and the ratio between the Bax/Bcl-2 proteins showed an increasing trend, indicating that 6b possesses the effect of promoting apoptosis (*** p < 0.001).

These results suggest a decreasing trend in the percentage of patients discharged to homes with increasing age ( p < 0.001).

Among hospitalised patients, ICU-admissions were also different by season throughout the study period and showed a decreasing trend (p < 0.001).

There was a decreasing trend in the mean HGS levels from CKD stage 1 to stage 4–5 in both men and women (p < 0.001) after adjusting for age and BMI ( Figure 2 ).

According to segmented regression analysis, there was a decreasing trend in the amount of aminoglycoside and quinolone consumption before the intervention ( p < 0.001 for each antibiotic) ( Table 2 ).

All groups showed a decreasing trend in the amount of swelling ( P <0.001).

Results In Brazil, over the 30-year period (1990–2019), leprosy incidence rates showed a decreasing trend, with an average annual percentage change drop of −1.1% per year ( P < 0.001) ( Fig. 1 ).

The adjusted ORs showed a decreasing trend relative to the reference category (elementary school or below): 0.67 (95% CI: 0.56–0.79, P < 0.001) for middle school, 0.55 (95% CI: 0.43–0.71, P < 0.001) for high school, and 0.48 (95% CI: 0.23–0.99, P = 0.048) for college or above.

We observed a decreasing trend in both procedures during the study period ( P < 0.001).

A decreasing trend of correct responses with increasing BMI classes from normal weight to overweight was observed for sour (the Cochran-Armitage trend test, Z = 1.8, p = 0.001), bitter ( p < 0.001), sweet ( p < 0.001), and water ( p < 0.01) stimuli.

The index of the four groups showed a decreasing trend as follows: CFBB/Zn 2+ /CS > CFBB/CS > CFBB/Zn 2+ > CFBB ( p < 0.001).

There was a decreasing trend in C-MMSE scores with increasing age and an increasing trend in C-MMSE scores with increasing levels of education, annual household income, and social support (all P < 0.001).

A significantly increasing trend in mean waist circumference, triglycerides, FBS, systolic blood pressure and diastolic blood pressure and a decreasing trend in mean HDL with increase in number of metabolic components were observed ( P < 0.001).

The results, shown in Table 7 , reveal a decreasing trend in BP across all three dietary changes, with a significant correlation between the changes and the decrease in BP ( P < 0.001).

After de-escalation training, the average duration of physical restraint of experimental group presented a decreasing trend ( F time = 9.174, P < 0.001) and was remarkably lower than control group ( F group = 5.054, P = 0.048) ( Figure 4 ).

The seven-year PV of Clostridium butyricum , Bacillus mesentericus , and Enterococcus faecalis was 10.9% with a decreasing trend (Z = -4.40, p < 0.001).

In terms of age, the SOCQ-general, ‘friends’ and ‘work/studies’ showed a decreasing trend (p<0.001), ‘acquaintances’ showed an increasing trend (p<0.001), and ‘family’ did not show differences among age groups (p = 0.333). ‘Social satisfaction’, measured by the VAS, did not show significant changes either by sex (p = 0.217) or by age (p = 0.262).

Overall, there was a decreasing trend in δ 13 C oto over the last century (main Year effect p<0.001), with a larger decrease observed in Icelandic cod (mean values of δ 13 C oto decreased by 0.7‰ over the past 100 years) compared to NEA cod (mean values decreased by 0.3‰ over the past 100 years) ( Table 2 , Fig 3 ).