“a clear trend”

Our analysis revealed a clear trend over the years (2016–2021) indicating a significant increase in nerve preservation among the patients we operated on ( p < 0.018, Figure 2 ).

There was a clear trend towards arresting the decline in renal function in the treatment group compared to the placebo group with a 42% reduction seen (0.37–0.93, P = 0.02), which was independent of baseline renal function or circulating SAA concentration.

Results Our study indicates a clear trend of increased overall spending per patient (r=−0.1232, p=0.02) and number of prescriptions per patient (r=−0.3440, p<0.001) in areas of higher deprivation.

Nevertheless, analysis of microarray expression data from TCGA [ 11 , 46 ] for 397 glioblastoma cases (Additional file 4 ) revealed a clear trend for core upregulated GNS genes to be more highly expressed in glioblastoma tumors than in non-neoplastic brain tissue ( P = 0.02, randomization test; Figure 3a ) and an opposite trend for core downregulated genes ( P = 3 × 10 -5 ; Figure 3c ).

Among women, there was a clear trend for increasing the remaining lifetime risk of HF from normoglycemia to T2D (p=0.02).

Still, although the difference between T1 and T3 was not significant, it indicates a clear trend towards increased satisfaction of the relatedness need over time ( M = 6.46; p = 0.021).

This decrease was significant in SAMR1, whereas SAMP8 showed a clear trend with mean values similar to SAMR1 astrocytes (ANOVA indicated an effect of CR treatment, F 1,23 = 6.009, P = 0.0222).

The T allele of TLR3 (rs3775291) SNP in a recessive model (TT) also showed a clear trend to increase the risk of the outcome (nominal P value = 0.024).

At the latest follow-up, outcomes in the control group remained stable without significant decline ( P = .568), whereas the MD-ACL group showed a clear trend toward deterioration, including a significant decline in IKDC scores ( P = .025).

Analyzing the discordant pair in Table 2 shows a clear trend of improvement from baseline to the end of treatment for TAP ( p = 0.02535/ p = 0.07364, without/with Edward’s continuity correction, respectively).

Albeit lacking statistical significance, there was a clear trend towards a reduction of mechanical ventilation (31% vs. 45%; wHR: 0.58 [0.36–0.94]; p = 0.026).

In fact, there was a clear trend between the levels of CD3 + cells and the severity of aGVHD (Figure 4 B; p = 0.028; Kruskal–Wallis test).

However, despite a clear trend of the DRG neurons to show a higher response than the TG neurons show, the difference becomes statistically significant only after two minutes of washout ( p = 0.0292 after two minutes and p = 0.0128 after three minutes of washout, unpaired Student’s t -test).

The multivariate analysis showed that all the lung function measurements analyzed, except FVC, were risk factors for wheezing in the past year ( Figure 2 ), but suffering from BPD, although it showed a clear trend, was no longer a risk factor for wheezing in the past year (OR 2.46 (95% CI 1.07–5.63), p = 0.03 for the model that included FVC, but OR 3.16 (95% CI 0.89; 11.18) p = 0.074 in the model that included FEV05/FVC).

Examining the raw data revealed that there is a clear trend to decreasing pCO 2 with increasing PMA ( p = 0.03; Fig. 1 ).

There was a clear trend towards more STIs (CT, NG and TV) in younger women ( p = 0.03), but numbers were too low to show significant differences individually ( Table 2 ).

The overall incidence of GSD was 0.632% per year (95% CI: 0.292%–2.009%), indicating a clear trend based on age (p = 0.03), where values monotonically increase.

DC-vaccinated patients who developed eosinophilia of 20% or more at any point during the course of vaccinations showed a clear trend toward longer survival ( p = 0.03; Figure 2 ).

Nevertheless, we see a clear trend where, of the CST types, CST I-A at baseline was most strongly associated with NILM at six-months (26/32, 81.2%, OR 0.32, 95% CI 0.12–0.82, p = 0.03, q = 0.15, Fisher’s exact test), while CST IV-A at baseline was most strongly associated with SIL outcomes at six-months (9/15, 60%, OR 3.07, 95% CI 1.03–9.40, p = 0.04, q = 0.16), however, the associations were only moderate when corrected for multiple testing (FDR < 0.2) (Fig. 2 a-b).

IPTp coverage by number and timing of ANC visits Among recently pregnant women, the mean number of doses of SP showed a clear trend with increasing number of ANC visits (p = 0.03) ( Figure 3 ).

There was a clear trend for increasing odds of seropositivity with increasing age: OR 1.6, 95% CI: 1.05–2.40 ( p = 0.03) for 5–14-year-olds and OR 8.13, 95% CI: 2.75–24.1 ( p < 0.001) for ≥15-year-olds compared to horses <5 years old.

More interesting, ELHB1L1 , another gene of the risk model, revealed a clear trend, but the risk-score is more meaningful ( P = 0.03).

Although geometric means are not significantly different ( P = 0.056) there is a clear trend towards higher HRP-2 in SM [OR = 1.42 (1.03 to 1.94), p -value = 0.031] (Table 2 ).

A Wilcoxon matched-pairs signed-rank test demonstrated a clear trend between the paired groups of CD39 + CD8 + T cell density (two-tailed, exact P = 0.0312).

We also measured a clear trend of pAbl Y245 downregulation in the CD34 + CD38 − population as a function of TKI-therapy (simple Wilcoxon test after 7 days of TKI P =0.0313).