Barely Significant
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“a clear trend”

19,461 sentences · 19,461 papers · 31,348 search hits before verification · confirmed specimen

Sighted at

p<0.09

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

Reflecting the development of NIV therapy in COPD, there is a clear trend of applying higher IPAP levels in order to achieve augmented ventilation and positive outcomes. 1 – 4 Of note, the current study observed that real-life IPAP levels reach a mean of 23 mbar, which is in line with recent RCTs by Köhnlein et al 3 (mean IPAP of 22 mbar) and Struik et al 4 (mean IPAP of 21 mbar).
While a larger Phase 3 trial did not reach significance for reduction in mild RTIs, there was a clear trend to improved immune function (Mannick et al. 2021 ). mTOR inhibitors therefore offer a therapeutic route to enhance ageing immune responses against viral pathogens for which we currently lack effective pharmacological interventions.