“a clear trend”

On the basis of consecutive 5-year RFS, PFS, and OS Kaplan–Meier plot validation, a clear trend of differences was observed between hypermethylation and hypomethylation of the SUMF2 gene at CpG_3 and CpG_7 Loci from tumor tissue.

S4 , there was a clear trend for downregulation of proteins that account for structural processes, calcium handling and antioxidant defense, mostly in the heart of ATII exposed mice: sarco/endoplasmic reticulum Ca 2+ ATPase (SERCA2a, −60%), mitochondrial manganese-superoxide dismutase (MnSOD, −45%), phospho-connexin 43 (pS325/328/330-Cx43, -20%) and total connexin 43 (Cx43, -30%).

A clear trend was observed between age of treatment and volume.

Among the three permeable membranes, a clear trend has been observed: As pressure increases, permeability increases almost linearly, consistent with transport mechanisms dominated by external forces.

The same pattern was observed for medium sound duration (209 ms; p < 0.001, mean summary statistics = 8.00; SD = 2.21; mean local features = 9.19; SD = 1.30), although there was a clear trend of decreasing average SNR with increasing sound duration in the summary statistics experiment ( Fig. 1 D ).

Only based on the estimates, a clear trend of elevated heritability in females is outlined in Figure 2 , which may suggest that in females, the bone mineral density is more genetically predetermined. 4.

A clear trend can be found that the percentage reduction of strength and elastic modulus increase with the increase of the ratio, R 0 .

Dissolved PO 4 3− showed a clear trend of decreasing with depth, with values of 8–10 μM above 50 m and < 2 μM below it (Figure 3c ).

Even if the association between these clusters and sensitivity was not significant (Fisher’s exact test p -value = 0.054), we observed a clear trend of enrichment of R patients in the cluster driven by Signature 1 and an enrichment of fS patients in the cluster driven by Signature 3 ( Figure 2 ).

Interestingly, exposure to DMSO in a dose‐dependent manner significantly downregulated gene expression of antioxidant enzymes SOD1 and SOD2 and showed a clear trend of reduction for SOD3 mRNA level (Figure 3A–C ).

Our long-term analysis shows high variability in precipitation and a clear trend in discharge, with a directional reduction in both streams over the study period.

There is a clear trend showing that an increasing dilution of the reservoir water samples is accompanied by a decreasing oxygen consumption rate.

Taken together, the results demonst were rate a clear trend in abrasion resistance, with PEBA showing the lowest material loss, followed by eTPU and TPU.

miR-148a showed a clear trend over time. miR-148a expression decreased initially after HKMT treatment but tended to increase after long-term exposure.

It can be seen that there is a clear trend of increasing MSE and astigmatism (both mean and median) with an increase in each of the four study variables.

The density of PLA-UTDPWF composite followed a clear trend, whereby the density increased with the filler content.

Despite the high variability of the technique, a clear trend was observed in 4TO-NOS cells showing higher amounts of S-nitrosated PRDX6 and PKM in Trx1-silenced cells than in control cells.

A clear trend emerged in both groups exhibited significant improvements in GRD, GRW, CAL, and WKG from baseline to 12 months, with the Test group consistently outperforming the Control group.

In the case of N749 , increasing the concentration of the sensitization solution from 0.05 to 1.00 mM did not lead to a clear trend in the variation of the resulting layer of N749 .

The PARA of FS and GL increased, whereas the parameters of other LUC types did not show a clear trend.

Partial GHD showed a clear trend toward intermediate levels, even though not significant when compared with the other two groups.

Due to the small number of cases, the difference was not statistically significant (p = 0.066), but a clear trend can be observed.

Plotting the ratio of the maximum LOD with iteration to that without iteration against the position of the maximum LOD with iteration shows that the LOD ratio is close to one when the maximum position is close to the middle of the chromosome but that there is a clear trend for the ratio to increase when the maximum position approaches the ends of the chromosome (Online Resource 2).

Notably, during the same period, there has been a clear trend of increasing national and international interventions to contain the pandemics.

Here, again, a clear trend emerges.