Barely Significant
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“a clear trend”

19,461 sentences · 19,461 papers · 31,348 search hits before verification · confirmed specimen

Sighted at

p<0.09

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

Cox proportional hazards models using the periodontally healthy dentate group as the referent population in unadjusted models demonstrate a clear trend and a gradient with increasing periodontal disease severity increasing the hazards ratios (HR) from 1.90 (95% confidence interval: 1.28–2.83) to 2.22 (1.44–3.41) and 4.66 (3.21–6.78) for edentulism.
Because the extensive metabolizer group has been broadly defined as having “at least one” active allele, an analysis was performed to determine if a semi-quantitative dose effect could be observed amongst different allele combinations.( 13 , 15 ) After assigning a score of 1 for each fully active allele, 0.5 for alleles with decreased activity, and 0 for inactive alleles/deletions, a clear trend towards decreased metabolism with lower semi-quantitative dose was noted with regards to peak metoprolol concentration and AUC (see Table 3 ).