“a clear trend”

In addition, both genes showed similar trends in different stages, with a clear trend of increasing PDL1 scores in stage IV and stage II–III, and an increasing trend of ACSS2 scores in stage I and stage II–III ( Figure 5 g,j).

The sunshine hours vary somewhat among provinces and cities and show a clear trend of fluctuation over time.

A clear trend of association with age was not observed.

Although future research may elucidate the downstream effects of SAHA, there is a clear trend toward its applicability with new drug repurposing opportunities because (i) it has a good blood-brain barrier permeability [ 4 ]; (ii) It does not lead to massive transcriptional changes; and (iii) compared to other HDACi, it is active at nanomolar concentrations in a variety of cellular and animal models [ 5 , 6 , 15 , 16 , 17 , 18 ].

Furthermore, the 20-to-24-nt tRNA reads display a clear trend towards a 5′ terminal Uridine residue (signature of preponderant Ago cargoes in mammals) only in TraPR- but not in Total-RNA libraries (Figure 5D ).

A clear trend was that pregnant APECED women overall had a relatively mild APECED phenotype: half of the women whose pregnancies ended with a livebirth had less than 4 APECED manifestations, which is less than average in patients with APECED ( 7 , 9 , 10 ).

However, their study demonstrated a clear trend toward decreased efficacy with later lines of treatment, which was not evident in our cohort when first-line versus subsequent-line therapy was compared [ 23 ].

A clear trend reversal towards an informed knowledge circulation across the circular economy model of single-use plastics is ultimately essential to develop sustainable solutions to reject the disposable culture, stop the waste of natural resources, and reduce the consumption of oil or gas for plastic production and thus protect the climate.

reported a prevalence of 49.3%, whereas studies published in 2017 or later showed a prevalence of 69.9% and 87%, respectively, indicating a clear trend towards an increased prevalence of dental caries among young children in Iran over the past 15 years [ 22 , 29 , 37 ].

29 , 30 Accordingly, in our study, we found a clear trend toward evidence of brain atrophy in RIS vs HCs, which is in keeping with previous studies that have demonstrated atrophy in brain regions of RIS, including whole-brain, cortical GM, and the thalamus. 14 , 31 , 32 In our study, the difference in brain atrophy observed in RIS vs HCs was likely of borderline statistical significance simply because of the small sample size.

In the present study, the value of the LF/HF ratio in the IUGR group tended to increase with gestational age; however, the value of CV RR did not show a clear trend.

Figure 7 shows a clear trend between transmittance and the amount of catalyst; this trend is higher for samples with less catalyst, which is in agreement with the results of the previous sections.

Our findings confirm the beneficial clinical effects of HMW-HA by both subjective and objective parameters at 10, 12, and 20 weeks compared to the saline control group including gross and histological grades of the synovium and a clear trend showing less severe articular cartilage lesions assessed grossly and histologically when compared with the control group.

When the bathymetric distributions of individual species are considered ( Figure 3 ), the upper and lower depth limits are usually found to be shallower in the more oligotrophic eastern basins than in the more eutrophic western basins [87] . Despite the differences in size fractions analyzed, when taken together, these data reveal a clear trend of decreasing species richness with depth, particularly in the South Adriatic Sea.

The above data indicate a clear trend of growing interest in this topic.

A clear trend is observed where increasing activator content from 10 to 14% enhances strength at all curing ages, owing to improved dissolution of binder particles.

Interestingly, data in this table can be compared with those in Table 1 , which showed a clear trend of consumed powder and cleaning efficiency.

The aHR increased to 1.17 (95% CI, 1.11 to 1.23) for those with DM duration <5 years, 1.23 (95% CI, 1.18 to 1.30) for 5–9 years, and 1.29 (95% CI, 1.24 to 1.34) for ≥10 years, indicating a clear trend of increasing risk with longer disease duration.

Statistical analysis revealed a significant difference in EF score distribution across the LBP severity categories (p=0.0036; F=5.23), indicating a clear trend of increasing EF with worsening pain severity.

Whilst there is a clear trend in uptake of the protocol following its implementation, it is evident that it is still not being used universally across the services.

7 , a clear trend with PMA is seen for duration and occurrence.

We conclude from these results that the compounded cue aCS+ has not become unblocked for the partner rat in the experimental group, however for the control group 1 we observe a clear trend indicative of unblocking.

Due to the high standard deviation for the width expansion, differences were not always significant, but a clear trend can be observed that bigel croissants were generally flatter and wider compared to the control croissants.

A subsequent analysis by Rudolph et al 20 reported a clear trend of lower graft survival with ≥12 h of CIT in pancreas transplantation.

This explains our results showing a clear trend towards higher CNR and lower noise levels.