Barely Significant
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“a clear trend”

19,461 sentences · 19,461 papers · 31,348 search hits before verification · confirmed specimen

Sighted at

p<0.09

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

Finally, meta-regression can also be used for the estimation of the effect of molecules under investigation or those without much clinical evidence; for example, after the results of the first long-term studies with inclisiran – the first RNA silencer therapy that inhibits the synthesis of PCSK9 – which reported the efficacy of monoclonal antibodies inhibiting the protein for lowering LDL cholesterol; moreover, a clear trend in the reduction of major cardiovascular events (MACE) was also observed.
The period from 2019 to the present is defined as the growth period, which has seen a clear trend of explosive growth, and the number of papers in 2022 (downloaded on 4 December 2022) has reached 107, an increase of 15.29 times in the last two decades, indicating that IHMs have attracted widespread attention and their use for haemostasis has been considered a research hotspot in the medical field.
The preliminary phase I/II clinical trials found a clear trend for improving PFS with the addition of olaratumab to chemotherapy, with a 31%–33% reduction in the risk of disease progression. 15 , 16 Tap et al. 16 demonstrated that olaratumab plus doxorubicin significantly improved OS in patients with advanced STS (26.5 vs 14.7 months; HR 0.46; 95% CI 0.30–0.71).
From conceptual DFT we reach values for electrophilicity that describe a clear trend from species II that is prone to undergo nucleophilic attack by the entering olefin: the substituted indenylidene catalysts 3 – 6 exhibit lower electrophilicity, especially when bearing the saturated backbone NHC, systems 3 and 5 .