“a clear trend”

Although no significant differences were observed, there is a clear trend towards more IL-32β and IL-32γ mRNA expression in the RA patients compared to the healthy individuals (Fig. 1A,B ).

Regarding metric families, a clear trend emerged: phase-based metrics demonstrated remarkable consistency.

While current guidelines recommend hormonal therapies such as combined oral contraceptives, gestagens, or GnRH agonists and antagonists [ 16 ], researchers constantly search for hormone-free alternatives, driven by a clear trend away from hormones in this particular patient collective, as well as lacking therapeutic options for women trying to conceive, yet suffering from severe endometriosis-associated symptoms, women for whom hormonal therapies are not adequate due to their contraceptive effect.

Nevertheless, together with the observed graded decline in mortality incidence across quartiles, the continuous eGDR variable analysis consistently confirmed a clear trend that an elevated eGDR level was associated with reduced diabetes mortality risk, which supports the potential prognostic value of eGDR.

Unfortunately, it is not present a clear trend between the amount of the ILs and the gas permeation properties.

Through Micro-CT analysis, newborn bone tissues in the hydrogel groups were arranged in an orderly manner, showing a clear trend of growth along the scaffold direction, while the appeared bone tissues of the blank group were disorderedly distributed and granular.

The figure also shows a clear trend of decreased absorbance as the degree of dysfunction progressed from normal to mild to severe NMEP to MEE.

In addition, in the literature, a clear trend was not found with the increase in the number of recycling loops.

Overall, there is a clear trend towards opiate overutilization with 12 studies observing a prescription rate of over 10 [ 3 , 5 , 8 , 22 , 23 , 24 , 26 , 27 , 28 , 30 , 31 , 32 ].

Figure 3 shows a clear trend in decreasing production of agricultural liming material over the last 40 years.

This reduction cannot be tracked with a clear trend, being highly different country by country, but it follows the trend of national public budgets.

A clear trend towards improved rates with increased frequencies of application is limited by intensified local and systemic reactions.

A clear trend emerges in all 12 food webs secondary extinction curves: the secondary extinction curves obtained by the tabu search-based algorithm had a higher slope at the beginning, and the collapse of the corresponding food web occurred faster.

Conclusion: Most of the studied parameters follow a clear trend of growth and change in size that correlates with maturity.

There is a clear trend in Br 2 concentrations in the aqueous phase at an SoC of 30% for the applied BCAs, which corresponds to the trend of BCA-concentrations in Section 2.3 : c(Br 2 ; [C6MIm]Br) < c(Br 2 ; [C6Py]Br) < c(Br 2 ; [C4MIm]Br) < c(Br 2 ; [C4Py]Br) < c(Br 2 ; [C3MIm]Br) << c(Br 2 ; [C2MIm]Br) < c(Br 2 ; [C2Py]Br).

The results revealed a clear trend where the current density decreased with decreasing carbonate concentration, which can be attributed to the reduced ionic conductivity of the electrolyte at lower concentrations.

The lack of significant increase in ERN/CRN amplitude in OCD patients compared with controls, despite a clear trend for the amplitudes of the ERN and CRN to be higher in patients (see Figure 3 ) contradicts a fairly unanimous previous literature (see [ 7 ]) but could be related to the specific characteristics of the patient sample.

Interestingly, we observed that the study hospital shows a clear trend toward improved patient safety, with a progressively lower complication rate regarding the control group over the years.

From the UV–vis absorption onsets, determined from the as-cast thin films, we determined the E g(opt) levels, which demonstrate a clear trend in the reduction of E g(opt) on increasing the conjugation length in the BXR series dropping from 1.92 eV to 1.74 eV.

Our data also show a clear trend toward first marketing application submissions and approvals in China, which was the case for ~60% of the molecules we included in these two categories.

Results indicated a clear trend where increased chitosan concentration led to higher water absorption values across all fabric types.

4 b) and a clear trend is observed, although variability inside each group is considerably large.

ECM deposition is not only regulated by MMPs and TIMPs, but it is also a target for growth factors; therefore, we evaluated gene expression of TGF-β and FGF-2. TGF-β mRNA levels were decreased after 12 days of reperfusion ( Figure 4(g) , p < 0.05), whereas the analysis of FGF-2 mRNA levels did not show any significant changes, despite a clear trend to downregulation in all I/R groups.

This analysis showed a clear trend where a large set of genes encoding for CI (26 out of the 79 detected) were overexpressed but in most cases only after 6 h of illumination, while their expression was not altered in ZT0 and ZT2.

One can observe that there is a clear trend toward slightly larger ligand field splittings when using multistate perturbation theory methods compared to the state-specific NEVPT2.