Barely Significant
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“a clear trend”

19,461 sentences · 19,461 papers · 31,348 search hits before verification · confirmed specimen

Sighted at

p<0.09

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

In contrast to VEGF, the anti-angiogenic factor TSP-1 showed no significant variation with the length of the blood incubation period, despite a clear trend for early upregulation and later downregulation ( Figure 3 B), which has previously been suggested to be a hypoxia-driven phenomenon that promotes the switch towards an angiogenic phenotype [ 15 , 37 ].
Although the IASLC R descriptors were not statistically significant predictors of OS ( p = 0.059; R(un) versus R0, HR = 1.54, 95% CI: 1.02–2.33, p = 0.040; R1/2 versus R0, HR = 1.45, 95% CI: 1.00–2.11, p = 0.051; R(un) versus R1/2, HR = 1.06, 95% CI: 0.69–1.63, p = 0.781), a clear trend was observed ( Supplementary Table 2 ).
Inspired by this, we set out to test an important question about the biological significance of cotranslational assembly: do large interfaces give rise to cotranslational assembly because of simple energetic reasons or do they reflect an evolutionary adaptation for a functional benefit? We found a clear trend across three evolutionarily distant species for the first translated interface of heteromeric subunits to be larger, suggesting that large interfaces have evolved to promote cotranslational assembly.