“a clear trend”

In a multicenter study of disopyramide, with a relatively low dosage, there was a clear trend toward lower sudden cardiac death mortality in disopyramide-treated patients with HCM (5) .

There was a clear trend towards increased recording of vaccination declines with increasing deprivation across priority groups (least deprived quintile: 0.9–1.5%, most deprived: 2.4–4.4% excluding care homes; Figure 2B ).

Indeed, the arrangement of viral taxonomic groups according to their average genome size revealed a clear trend ( Figure 1 ).

Several adhesion molecules, Tnr, Cadh11, Pcdhgc3, and Sema6d, were also significantly regulated with a clear trend for downregulation in both forms of scaling ( Figure 5 ; Tables S2 and S4 ), reminiscent of earlier studies showing that downregulation of adhesion is required for structural plasticity at synapses ( Mayford et al., 1992 , Schuster et al., 1996 ).

Simultaneously with preclinical research remaining foundational, a clear trend towards human-based studies is evident, while focusing on measures for its safe usage, to avoid its undesired effects.

The 10 patients who had not developed recurrence by the end of the study period had serum CA19–9 levels of 7 IU/L (range <2–13 IU/L), but in those patients who had recurrent disease, the serum CA19–9 level showed a clear trend of increase during the post-operative period, and at the time of a documented radiological recurrence, the serum CA19–9 level was 1818 IU/L (range 75–7049 IU/L). 4.

The development of the peak heights do not follow a clear trend (insets of Fig. 2 ) and for nearly all datasets they remain stable over time (see Supplementary Fig. 5 for full distributions, the exception of Wikipedia is discussed in Supplementary note 1).

We found a clear trend where genes that are highly divergent in response between species are also more variable in expression across individual cells within a species ( Fig. 3a ).

A clear trend is observed in the coercivity values, which decrease with increasing film thickness.

Considering that the expression profiles of GSH cell lines were very similar and the BioBricks were at different loci, the genomic perturbations did not follow a clear trend linked to the transgene insertion.

It is difficult to indicate a clear trend of the variability of the deformation mode with the change in design parameters (n radial and n circus ) in the conducted range of the experiment.

Echocardiographic parameters demonstrated a clear trend toward atrial enlargement and functional impairment in the POAF cohort.

Further, we observed a clear trend in improved functional language use after MIT: subacute aphasic patients receiving MIT improved considerably on language tasks measuring connected speech and daily life verbal communication.

Post hoc analysis using the Tukey test revealed a clear trend: increasing the proportion of buffalo milk in camel milk led to higher numbers of ripening holes in cheese samples.

Our meta-analysis revealed a consistent, robust correlation between anti-tTG antibody levels and the histological severity of celiac disease, with a clear trend of increasing antibody levels corresponding to the severity of mucosal damage.

Overall, Table 7 demonstrates a clear trend: as water turbidity increases, the required SNR for reliable communication rises, with higher-order modulations Like 64-QAM and 32-PSK being especially sensitive to changes in water type.

Compared to the influence of input time window and threshold time resolution on feature importance, the variation in contributions due to threshold levels was minimal and did not exhibit a clear trend.

Furthermore, si VPS34 significantly induced expression of IRF3 target genes IFNB1 , IRF7 , and CCL5 and showed a clear trend to increase CXCL10 (Fig.

Additionally, the model sizes of YOLOv5n and YOLOv11n were measured to be 5.02 MB and 5.21 MB, respectively – approximately 73% smaller than that of YOLOv3 (19.3 MB, demonstrating a clear trend toward model miniaturization.

Considering that this study focuses on the characterization of the crude pecan shell extracts, the lack of a clear trend by extraction temperature is not surprising (Fig. 3 ).

When compared with non-suction assisted PCNL, despite the wide heterogeneity of techniques and patient cohorts, a clear trend is evident towards a reduction of overall infectious and bleeding complications in aspiration-assisted procedures, alongside equivalent or better SFRs.

In high take-off (compared to low) prolapse, we found significantly more caudal descent of the RSJ during straining and there was a clear trend to lower RSJ position at rest.

The precise contribution and interdependence of NADPH oxidase and mtROS to AM anti- Aspergillus activity remain to be determined, though it is notable that both rotenone- or carbonyl cyanide 4-(trifluoromethoxy) phenylhydrazone (FCCP)-treated macrophages in vitro ( 34 ) and mtH 2 O 2 -neutralized AMs in vivo both exhibit a clear trend to decreased antifungal activity when NADPH oxidase is either pharmacologically blocked (i.e., diphenyleneiodonium chloride [DPI]) or genetically ablated.

Increased concentrations of PCT were strongly associated with bacterial infections in all four cohorts for both the PERFORM and SBI algorithms, and the PERFORM classification algorithm showed a clear trend toward higher concentrations of PCT in children with a higher degree of certainty of having a bacterial infection ( Figure 3 ).

A clear trend dependent on the prescription isodose line was only observed for target minimum dose indices such as PTV D95 and D98, but not for the mean/maximum dose indices such as Dmean, D5, or D2.