Barely Significant
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“a clear trend”

19,461 sentences · 19,461 papers · 31,348 search hits before verification · confirmed specimen

Sighted at

p<0.09

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

These immunofluorescence experiments revealed a statistically significant increase of detyrosinated α-tubulin in mdx CMs compared to WT CMs, a clear trend towards an increase in total α-tubulin, in line with previous findings showing an increase in density of the MT network, 6 , 7 , 10 , 11 , 14 , 15 and a significant increase in the ratio of detyrosinated α-tubulin on total α-tubulin ( Figure 1 B ).
At the planned primary analysis of the all-comers cohort, the median rPFS was not yet reached in the experimental arm for the intention-to-treat cohort, with a clear trend favouring the combination (NR vs 21.9 months, HR 0.63 [95% CI 0.51–0.78], p = <0.0001), suggesting that the combination confers a clinically meaningful benefit regardless of HRR status [ 59 ].
However, a clear trend was observed: the RR progressively decreased as baseline BEC increased, suggesting a potential therapeutic benefit of mepolizumab for patients with higher levels of eosinophilic inflammation. 2) Confirmatory evidence from the MANTINEE trial The lessons from METREX and METREO informed the design of the MANTINEE trial, a large phase 3 study specifically aimed at confirming the therapeutic benefit of mepolizumab in an eosinophilic COPD population [ 22 ].