Excerpts

The correlation between RNA-seq fold changes computed on the data from day 2 versus that from day 4 was highly significant (r = 0.50, P<10 −16 , Figure S2A ).

It exhibits highly significant protein interaction enrichment ( p < 1 × 10 −16 ).

Follow up genotyping of 70 rare and low-frequency protein-altering variants (MAF ~ .001-.05) in nine independent case-control series (16054 CD patients, 12153 UC patients, 17575 healthy controls) identifies four additional independent risk factors in NOD2 , two additional protective variants in IL23R , a highly significant association to a novel, protective splice variant in CARD9 ( p < 1e-16, OR ~ 0.29), as well as additional associations to coding variants in IL18RAP, CUL2, C1orf106, PTPN22 and MUC19 .

Statistical analysis (MANOVA) of the original data obtained from the cell populations indicated a highly significant difference between them (p<10 −16 ) suggesting that the nuclear SIRT1 pattern reflects structural differences in the nuclei between the cell populations.

The correlation between HNRNPK binding events and nuclear enrichment was highly significant when controlling for transcript length and expression levels (R=0.2, P<10 -16 in HepG2 cells and R=0.07, P<10 -16 in K562 cells).

The difference of the average log2-scaled metformin levels in blood between both groups was highly significant ( p < 10 −16 ).

For our list of 64 miRs, 18 enrichment pathways are highly significant ( p < 1E-16).

Statistical analysis revealed a highly significant PPI enrichment ( p ‐value < 1e −16 ).

The network displayed an average target degree of 4.97 and a local clustering coefficient of 0.514, indicating a highly significant PPI enrichment (p-value <1.0e-16).

Again, this is highly significant ( P < 10 -16 , Wilcox rank test).

The analysis revealed a highly significant interaction network among the differentially abundant proteins ( p < 1.0 -16 ), indicating that down-regulation of these protein interactions may play a crucial role in modulating intracellular biological processes in pigs fed a BET diet. 3.2.

Comparing gametic disequilibrium between high-sugar and control populations for SNPs showing positive selection unique to the high-sugar regime revealed a small but highly significant negative correlation (r = −0.06, P < 10 −16 ).

When we compared RtAI and the number of HGT events of each COG (again controlling for the fact that some genes appear in fewer organisms; see ‘Materials and Methods’ section) we, once more obtained a highly significant correlation ( r = −0.4125 and P < 10 −16 , pe < 0.001; n = 917).

All were highly significant ( p < 10 –16 for all chromosomes after Bonferroni correction), with over 96% of the variation in the F5 position being explained by the F2 position for every chromosome tested ( Figure 2 ).

We also created protein interaction networks of non-plaque tissue DS, EOAD, and LOAD proteomes, which showed a highly significant degree of protein–protein interactions (PPI enrichment p = 1 × 10 −16 , Supp.

Using STRING analyses, we identified a highly significant protein–protein interaction (PPI) enrichment ( P = 10 −16 ) only for the downregulated genes of H2A.Z.1‐depleted cells.

Figure 3 illustrates the interactome for DS3, featuring 257 edges, 57 nodes, an average node degree of 9.02, and a highly significant PPI enrichment p -value of <1.0 × 10 −16 .

In spite of different cell death phenotypes of these mutants, RNA-seq revealed that all three mutants down-regulated the same 95 genes and up-regulated the same 9 genes, a highly significant portion of the total transcriptome (p<10 −16 ) ( Figure 5 and Table S5 ).

The difference between the two distributions was highly significant ( p < 10 −16 , two-sided Wilcoxon rank-sum test).

The global mediation test reveals a highly significant result ( p < 10 − 16 ) and low neutralization rate (21%), confirming that CT imaging strongly mediates the effect of PRS on FEV1.

Moreover, pairwise Levene’s tests for equality of variances between ancestry tracts were all highly significant ( p < 1 × 10 −16 ).

In particular, there was a highly significant overlap ( p < 1E-16, one-sided Fisher’s exact test) between the top 56 enriched cytobands from the CBTN cohort and a top set of 79 enriched cytobands from the PCAWG cohort, involving 29 cytobands (Figure S1e).

DAPs Are Involved in Wound Repair and Blood Coagulation Are Associated with Hydration Protein–protein interaction analyses of DAPs using STRING [ 19 ] resulted in a highly significant clustering (PPI enrichment value of p < 1.0 × 10 −16 ) consisting of 34 nodes and 126 edges ( Figure 2 ).

The resulting network showed a highly significant interaction among the proteins (p value < 1.0e −16 ).

The network comprised 65 nodes and 400 edges, with a highly significant PPI enrichment p-value of < 1.0 × 10−16(Fig. 1 B).