The resulting network showed a highly significant interaction among the proteins (p value < 1.0e −16 ).
Excerpts
Notably, the results of this analysis showed that the majority of the proteins (73 of the 81 submitted proteins) are connected within a single network, with a highly significant protein-protein interaction enrichment (p-value < 10 −16 ) (Fig. 1A ).
Despite the different experimental conditions, we found a highly significant overlap (odds ratio [OR] = 27, P < 10 −16 ) ( Fig. 1 C).
Results Pairwise scores enrich for genetically similar samples when considering MB data only (odds ratio: 17.3), GT only (odds ratio: 6.1) and a combination of both (odds ratio: 19.8), with highly significant P-values for all ( P < 10 −16 ).
There were highly significant differences in flowering ( F 3, 379.07 = 473.2, P < 1 × 10 −16 ) and green-up ( F 3,416.03 = 110.5, P < 1 × 10 −16 ) among the grandparents.
The highly significant protein–protein interaction network ( p < 1.0E-16) was created with 378 nodes, 810 edges, 4.29 average node degree, and 0.357 average local clustering coefficient ( Figure 13A ).
One-way analysis of variance (ANOVA) using the cluster size as the factor variable found that both results are highly significant ( P < 10 −16 ).
The network showed highly significant PPI enrichment (p < 1.0 × 10 −16 ), with an average node degree of 3.52 and a local clustering coefficient of 0.497, supporting the presence of a non-random and moderately clustered interaction structure.
We do detect a highly significant enrichment of marine-freshwater differentially expressed genes, as predicted ( P < 10 −16 ).
It exhibits highly significant protein interaction enrichment ( p < 1 × 10 −16 ).
The network comprises 26 nodes and 131 edges, with a highly significant PPI enrichment p < 1.0e-16.
The difference in degree of nucleotide conservation between the IDR and the remainder of the molecule is highly significant ( P <10 −16 ), and indicates a dramatically higher level of divergence for the IDR-encoding portion of the mammalian TS transcript.
Protein–protein interaction (PPI) analysis revealed a highly significant network connectivity among these proteins ( p < 1.0 × 10 −16 ).
Moreover, using paired t tests to validate these differences, we found highly significant differences between the observed distributions of FD and PD and the null models ( P < 10 −16 , t test).
DAPs Are Involved in Wound Repair and Blood Coagulation Are Associated with Hydration Protein–protein interaction analyses of DAPs using STRING [ 19 ] resulted in a highly significant clustering (PPI enrichment value of p < 1.0 × 10 −16 ) consisting of 34 nodes and 126 edges ( Figure 2 ).
However, when considering the overall number of associations per source and the number of highly significant associations (-log 10 (p) ≥ 16), clear differences emerge.
In other words, organisms sampled from a defined skin habitat were more similar to each other in 16S sequence than expected for a global background; this enrichment was statistically highly significant (p<<10 −16 , one-sided Mann-Whitney-U test, see Table S1 ).
Hub genes from PPI network Key targets were imported into the STRING database to construct a PPI network comprising 236 nodes and 3,711 edges, with highly significant enrichment ( p < 1.0 × 10 −16 ).
Each result is highly significant ( p < 10 −16 , for each predictor.
Starting with the GO gene sets, we found a highly significant enrichment in genes related to the innate immune response particularly (p = 1.×10 −16 , FDR = 1.36 × 10 −12 ).
Changes in mean activation magnitude in both regions between unscaled and scaled t-values are of the order of 10% of unscaled activation magnitude and are highly significant (a t-test over all voxels yields a p-value of p < 10 − 16 ).
The network comprised 65 nodes and 400 edges, with a highly significant PPI enrichment p-value of < 1.0 × 10−16(Fig. 1 B).
However, the overlap between the two categories of the intergenic transcribed regions is highly significant (P-value < 10 -16 , chi-square test)." Contributor Information Philipp Kapranov, Email: [email protected].
We also created protein interaction networks of non-plaque tissue DS, EOAD, and LOAD proteomes, which showed a highly significant degree of protein–protein interactions (PPI enrichment p = 1 × 10 −16 , Supp.
This evidence of highly significant PPIs (actual edges = 1015, expected edges = 405, P < 1.0 × 10 −16 ) and highly ASD-relevant GO BP enrichment showcases a clear example of how the PFC sex*genotype DE genes are embedded within a complex systems-level biological pathology that integrates abnormalities along these key processes and pathways.