Excerpts

Differences between groups in D, H, and W were highly significant (ANOVA, p < 10 −55 ) ( Figure 2 and Figure 3 ).

After adjustment for KIV number, the association became highly significant also in the total population ( P = 1.05e-55) and in the HMW group (KORA F4 HMW: P = 1.69e-10).

In lung adenocarcinoma tissue, CHRNA5 showed a modest positive association with (AD: Z = 2.36, p = 0.018) but a highly significant negative association with lung cancer (LC: Z = −15.72, p = 1.17 × 10 −55 ).

A highly significant deviation from HWE of the homozygous carriers of the alternative allele (rs110593220) was detected within the 2,612 samples with χ 2 = 252.97 (p = 1.2e-55).

Gene Ontology enrichment analysis of the 155 genes in cluster 4 demonstrated a highly significant enrichment for biological processes linked with S phase including DNA replication ( P = 1.58 10 −55 ), DNA repair ( P = 1.31 10 −39 ) and G1/S transition ( P = 4.3 10 −26 ) (Fig. 1c , blue barplots).

Therefore, we examined this group of downregulated transcripts and found a highly significant enrichment of FMRP target genes (p=2.59e-55) ( Darnell et al., 2011 ).

When we compared these data to the breakpoint homology from 16,783 CNV breakpoints assembled for the 1,000 Genomes Pilot 1 study using identical methods, we find a highly significant difference from either the BWA-SW analysis (χ 2 = 244.6, 1 d.f., p = 2.6×10−55) or the EMBOSS method (χ 2 = 201.6, 1 d.f., p = 1.26×10−45) ( Fig. 3 ).

advanced paternal age blastocyst DNA methylation epigenetics offspring neurodevelopmental disorders sperm A statistical comparison of the sperm and blastocyst DMR‐associated genes demonstrated a highly significant enrichment of genes between the two methylomes upon paternal aging ( p = 3.46 × 10 ‐55 ; odds ratio [OR] 3.19).

The Kruskal–Wallis test for different message intervals shows a highly significant difference for the C++ node, with p = 3.49 × 1 0 − 55 , and for the Python node, with p = 1.98 × 1 0 − 58 .

A hypergeometric test confirmed that this overlap was statistically highly significant (p=4.6e −55 ).

The modest but highly significant K9me2 gene body correlation with expression (Spearman ρ = −0.114, p = 6 × 10− 55 ) confirms functional relevance at individual loci. 4.2.

Using SEA with the ChEMBL database, SNAP was predicted to target human protein PHLPP1, with a maximum Tanimoto coefficient of 0.31 and a highly significant p -value ( p = 8.8 × 10 −55 ) 46 .

Statistical significance was assessed against the two different control models using one-sided Mann–Whitney U tests, which yielded highly significant p -values ( p = 9.83 × 10 −55 and p = 4.94 × 10 −44 respectively).

The highly significant (P < 10 −54 ) preference for TGT codons at Cys 104 , but not Cys 23 , suggests selection for site V recombinogenic sequence that is independent of the amino acids necessary for BCR structure.

This was highly significant for circTai (7.2-fold enrichment, p < 1 × 10 −54 ; Figure 1 D) and circCt (2.6-fold enrichment, p < 1 × 10 −31 ; Figure 1 E).

They identified a highly significant SNP (rs77924615; p = 1.5 × 10 –54 ) in the UMOD gene associated with eGFR.

We also performed eQTL analysis using published data (Blood eQTL Browser: http://genenetwork.nl/bloodeqtlbrowser/ ), and found that three candidate variants showed highly significant association with the expression of EP300 in blood ( P =1.64×10 -54 for rs2076578, P =3.63×10 -54 for rs575825, and P =3.26×10 -54 for rs2143694), suggesting that these variants are probably involved in the expression regulation of EP300 .

Crucially, statistically significant separation of the two conditions ( p < 0.05) was achieved for all participants from both tasks, and highly significant separation of the classes was shown at the group level ( p = 2.8 × 10 −54 and p = 9.6 × 10 −62 for the Task 1 and Task 2, respectively).

The statistical significance (−log 10 P value) for each term in the PGC GWAS and the SCHEMA study showed a highly significant correlation (Fig. 2b , Pearson’s correlation coefficient = 0.39, P = 6.67 × 10 −54 ).

We cross-referenced this list with our RNA-seq data and found that ∼35% of differentially genes in the Bend3 KO relative to WT are bivalent; this is a highly significant enrichment ( P = 8 × 10 −54 , Figure 4C ).

As expected, all 6 biosets exhibited highly significant similarity to the STAT5b biomarker (p-values ≤ 10 −53 ).

The result of the LR test is highly significant (P < 10 -53 ).

itive individuals, making them suboptimal controls for this analysis. Fine mapping of the LYZ eQTL effect of the resistance-associated variants The resistance-associated variants of the 12q15 locus are in strong linkage disequilibrium ( r 2 > 0.8) and were included in the analysis because of their highly significant eQTL effect on the LYZ gene in whole blood (e.g., rs622656 eQTL normalized effect size (NES) = − 0.55; P = 1.2 × 10 −53 ) and the lung (rs622656 eQTL NES = − 0.35; P = 4.7 × 10 −21 ) in GTEx v8.

The sex-biased difference in UBA1-CDK16 expression was found to be highly significant ( P = 2.7 × 10 −53 ) ( Fig. 1H ).

Within this interactome, we identified a highly significant ( p < 10 –52 ) smaller network ( Figure 4 ) showing enrichment for the HNF4α pathway.