Specifically, the inhibition zones generated by 1R6F AqEx were highly significant ( p < 0.0001) compared with PBS and significantly larger than those induced by IQOS AqEx (for S. pneumoniae, p = 0.002; for K. pneumonia , p = 0.002).
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The Wilks’ lambda statistic was extremely low at 0.00303, corresponding to a highly significant approximate F-value of 17.353 ( p < 0.0001).
The combination between SCF and LRG1 showed highly significant difference in CRC patients compared with benign, healthy subjects, and among CRC groups (treated and non-treated) ( p < 0.0001).
There was a highly significant repeated measure effect of time bins, suggesting changes in freezing as the testing session progressed (F(5,12)=105.05, p<0.0001), but no between group difference (F(1,16=0.61, ns) nor interaction effects (F(5,12)=0.97, ns).
Expressing the survival as CFU/ml instead of as percentages however reveals a highly significant difference between the strains in the actual number of surviving bacteria at 2, 9, and 21 h post-penicillin addition ( P < 0.0001), which again can be explained as a significant strain dependent difference in invasiveness (Figure 5 ).
Concerning attention behavior during familiarization, a repeated-measures ANOVA with looking time as dependent measure, language group (Catalan, Spanish, bilingual) and familiarization condition (TB or GM) as a between-group factors and trial (first, last) as repeated measures revealed a highly significant effect of familiarization trial [ F (1, 48) = 42.9; p = 0.0001; η 2 = 0.47], and no effect of language group or condition and no significant interactions [familiarization trial × language group: F (2, 48) = 1.15; p = 0.32; η 2 = 0.04; familiarization trial × condition: F (1, 48) = 1.7; p = 0.19; η 2 = 0.03; familiarization trial × language group × condition: F < 1].
The non-parametric one way ANOVA of prediction scores distribution among categories was highly significant for all three metapredictors ( p < 0.0001 for all predictors with VEST3 Kruskal-Wallis statistic K = 156.1, REVEL Kruskal-Wallis statistic K = 113, ClinPred Kruskal-Wallis statistic K = 168).
Highly significant differences ( P <0.0001; Mann–Whitney) were seen between concentrations of these variables in patients with metastatic disease compared with localised disease ( Figure 1 ) with median values (IQR) respectively of 22.2 (4.2–111) vs 5.7 (0.6–11.5) mg l −1 for CRP, 189.2 (114.8–303.4) vs 82.3 (575.5–131.1) μ g l −1 for OPN and 186.4 (89.6–336.2) vs 102.5 (61.6–153.9) μ g l −1 for CA9.
The overall effect of thickness on curling degree distribution was highly significant (likelihood-ratio test, p < 0.0001).
The detection accuracy of culture and PCR was assessed, and the coefficient of accuracy (k) was highly significant in the healthy (0.3103; P < 0.0001) and CP groups (0.1536; P < 0.0497).
The breadth of the responses to the 11 epitopes showed highly significant correlations with both lower pVLs ( P < 1 × 10 −4 ; r = −0.4909) and higher CD4 counts ( P < 1 × 10 −4 ; r = 0.4542) in these Japanese individuals ( Fig. 8B ).
However, there were a significant increase in DBP and an extremely significant decrease ( p < 0.0001) in the pulse rate after the intervention. 3.3.
Regarding schistosomiasis, cysteine peptidases, such as papain, Schistosoma mansoni cathepsin B1 (SmCB1) and cathepsin L3 (SmCL3) and Fasciola hepatica cathepsin L1 (FhCL1) do not induce allergic reactions in mice or hamsters and were shown instead to elicit reproducible and highly significant ( P < 0.0001) reduction of 50–65% in challenge S. mansoni and Schistosoma haematobium infection, via generation of polarized (papain, SmCL3, FhCL)- or predominant (SmCB1) type 2 responses involving release of TSLP, IL-4, IL-5, IL-13 and generation of IgG1 antibodies [24] , [25] , [26] , [27] , [28] .
There was a highly significant relationship between the level of pCVI988 measured by the two q-PCR systems (p < 0.0001, Fig. 5 a), and between the level of RB-1B measured by the two q-PCR systems (p < 0.0001, Fig. 5 b).
In comparison to ∆ odc mutants supplemented with polyamines, the difference was highly significant, with p < 0.0001 observed on days 4, 7, and 10.
The results showed highly significant and strongly positive correlations in all subsets: CD3+ T cells (r = 0.92, p = 0.0001), CD19+ B cells (r = 0.96, p = 0.00001), NK cells (r = 0.93, p = 0.00009), and NKT cells (r = 0.90, p = 0.0004).
Two-way ANOVA statistical summary demonstrated that the clinical status had a highly significant impact on these levels (F (1, 36) = 26.59, p < 0.0001).
The Friedman test indicated a highly significant overall reduction in pain scores across these time points (χ2(6) = 104.2, P < 0.0001).
This showed that treatment with both hiEV preparations exerted strong and highly significant reductions in trabecular bone volume fraction compared with untreated DMM joints (BV/TV% hiEV_serum: Beta = − 12.84, P = 1 × 10−4; hiEV_PS: Beta = − 9.94, P = 3.93 × 10−4).
Permutational multivariate analysis of variance confirmed that compositional differences among the three associations were highly significant (F = 7.658, p = 0.0001, 9 999 permutations), a result corroborated by the rank-based test of similarity ( R = 0.6135, p = 0.0001).
The Log rank test indicated highly significant differences in survival among the three groups (p < 0.0001).
K S and the block size show a strong negative correlation, and Pearson's correlation coefficient is r = −0.288, which is highly significant ( p <0.0001, permutation test).
The qualitative Itoh score was also a highly significant predictor of malignancy (p< 0.0001).
After grouping patients with MC in active and in remission, a highly significant difference in median FC concentrations between active MC and IBS groups ( P <0.0001) was identified ( Table 3 ), whereas median FC concentrations of patients with MC in remission did not significantly differ from patients with IBS ( Table 3 ).
Remarkably, we found a significant trend of reduced N expression from BA.2 to XBB.1.5 in mice of all three age groups, including weanling mice (−R = 0.79, p < 0.0001), adult mice (−R = 0.73, p < 0.0001), and aged mice (−R = 0.73, p < 0.0001) ( Fig. 6 d).