Excerpts

A highly significant difference ( p < 0.0001) was observed between the 2:1 treatment, and both 1:1 and PFOA only treatments, with respect to lethal concentration and apparent neurobehavioral effects, suggesting an effectively reduced toxicity of the fully complexed PFOA.

In Figure 2 as well as in Figure 3 of their study ( 1 ) they demonstrated a clearly significant difference between the TYM scores between controls and AD patients as well as between moderate AD and severe AD patients (both p < 0.0001).

group II (0.972±0.505 ng/ml), and the differences were highly significant (p<0.0001).

* indicates p‐value 0.01 to 0.05 (significant) ** indicates p‐value 0.001 to 0.01 (very significant) *** indicates p < 0.001 (highly significant) **** indicates p < 0.0001 (extremely significant) 4.14.

Identifying Unreliable Primers Bartlett's test of heteroscadasticity (unequal variability within groups), applied to the residuals of each linear model fit by (1), is highly significant ( p < 0.0001).

65,66 Statistical analysis confirmed these reductions were highly significant ( p < 0.0001) compared with the EAC control.

Along with expected improvements in clinical and lung function parameters brought by Mepolizumab treatment, FEF2525-75% values showed a highly significant, gradual and persistent increase (from 32.7 ± 18.2% at baseline to 48.6 ± 18.4% after 18 months) and correlated with ACT scores at 18 months (r = 0.566; p ≤ 0.0001).

The rise in seroprevalence between 2023 and 2025 was highly significant across sexes, regions, and provinces (p < 0·0001; Table 2 ).

A multivariate analysis of variance showed that while role had a highly significant effect ( p < 0.0001) on the content of the communications, neither gender nor the order in which roles were assumed had a significant influence.

The observed increases in coronary pressure gradient, stenosis resistance, and flow velocity did not reach statistical significance; however, the diastolic velocity–pressure gradient relation was consistent with a significant increase in relative stenosis severity (k coefficient, P <0.0001), in keeping with exercise-induced vasoconstriction of stenosed epicardial segments and dilatation of normal segments, with trends toward reversal with nitroglycerin.

Comparing the titer of IgG directed against the RBD of the spike glycoprotein of the SARS-CoV-2 (anti-RBD IgG) measured with chemoluminescence assay and the neutralizing capacity of the serum, we observed a highly significant ( P < 0.0001) and strong ( r 2 = 0.67) positive correlation ( Figure 3 g).

The difference between the two PD severity cohorts was highly significant ( p < 0.0001), indicating that APS is a more sensitive method than RRS or BWS ( p = 0.1896 and 0.0020, respectively; Fig. 1l ).

Moreover, the correlations between the concentrations of free and total (free plus conjugated) species of methyl and n- propyl parabens were highly significant ( p < 0.0001 and p = 0.0096, respectively; Figure 2 ).

These values exhibited highly significant differences ( p ≤ 0.0001 ) between automatically-generated vs. manually-generated tracks.

S3 and Table S4) revealed highly significant ( p -value <0.0001) influences of the sampling time, type of compound, and CP.

A significant reduction (*** p = 0.0013) in total body weight after treatment with SEM was observed in the SL group and a highly significant reduction (**** p < 0.0001) was observed in the SM and SH groups.

A cutoff of 8.8 for max SUVmax advocated in our previous report was highly significant ( p < 0.0001).

The results presented in Table S3 showed that the model was highly significant (F-value = 69.52, p < 0.0001).

Meta‐Analysis of Butyric Acid Concentration in Patients With Periodontitis Meta‐analysis indicated an overall decreasing trend in butyrate levels in GCF or saliva from patients with periodontitis; however, the difference did not reach statistical significance (SMD = −1.58, 95% CI: −6.53 to 3.36) and heterogeneity was substantial ( I 2 = 90.9%, p < 0.0001; Figure 3 A).

The differences in mean antibody response levels between the groups for both net OD 1.0 and OD 1.0 ratio 2 weeks after third vaccination were highly significant ( P < 0.0001, Kruskal-Wallis test).

OMP treatment reduced TGF-β1 levels to 180.7 ± 2.82 pg/mg protein, whereas GLY-NPs dropped it further, to 90.83 ± 2.41 pg/mg protein, with all intergroup comparisons being highly significant ( p < 0.0001) ( Figure 8 A).

Across all responses, the positive coefficient of the curing period (Factor B) was found to be highly significant ( p < 0.0001), indicating that longer hydration time is the strongest contributor to strength development, primarily due to progressive hydration and pozzolanic conversion of SCMs into additional C–S–H gel.

Intragroup reductions from baseline remained highly significant at all time points in both groups (p = 0.0001).

The line differences in both traits were highly significant ( p < 0.0001).

The treatment effect was initially large, although after adding studies with large sample sizes, the confidence interval narrowed, and the treatment effect became smaller and stable, albeit the treatment effect was still highly significant (P<0.0001).