Barely Significant

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highly significantP = 0.00010.0× alphaqualifiedgold
After 9999 permutations, Adonis2 (PERMANOVA) analysis on the same Hellinger transformed and batch corrected data indicates that rumen community structure is highly significant ( P = 0.0001) with regard to the diet, as well as significant ( P < 0.05) in all pairwise comparison between each diet.
highly significantp<10 −40.0× alphaqualifiedgold
When comparing allelic frequencies between HIV-controllers and the PRIMO seroconverters, four SNPs located within the 6p21 (rs2395029, rs13199524, rs12198173 and rs3093662, are in bold in Table 1 ), showed highly significant differences (p<10 −4 ) that correspond to a striking enrichment in HIV-controllers for protective allelic variants associated with HIV-RNA levels.
highly significantp < 0.00010.0× alphaqualifiedgold
Marble burying was strikingly increased by both treatments and two-way ANOVA revealed a highly significant effect of time (F = 49.16, df 1,47 p < 0.0001) and treatment (F = 12.67, df 2,47 p < 0.0001) and a significant time X treatment interaction (F = 12.67, df 2,47 p < 0.0001) (Fig. 6D ).
highly significantp<0.00010.0× alphaqualifiedgold
As shown in Fig 2 , plaques formed in the RAP-treated cultures were smaller and less numerous (mean = 199.3, SD = 9.2, n = 54) than those formed in the control wells (mean = 329.1, SD = 6.7, n = 205), with a two-tailed independent t-test revealing this difference to be highly significant (t = 9.290, d.f. = 257, p<0.0001).
highly significantp < 0.00010.0× alphaqualifiedgold
TotDis during the AC and NS periods (proxy for exploration) did not significantly vary between feed treatments (χ 2 = 0.46, df = 3, p = 0.93) (see Figure 7 ), but there was a highly significant effect of TL (χ 2 = 71.4, df = 1, p < 0.0001), i.e., the higher the TL, the lower the TotDis. 3.3.2.
highly significantP < .00010.0× alphaqualifiedgold
However, patients with a high FRET efficiency (Fig 4 B) had considerably better survival (highly significant P < .0001) in first-line treatments compared with low FRET patients (median 50% survival still undefined after 50 months for high FRET v 11 months for low FRET patients).
highly significantp < 0.00010.0× alphaqualifiedgold
The data presented in Figures 1(a) and 1(b) demonstrates that there was a highly significant increase in the expression of miR-181a-5p (4.56 ± 0.92-fold change, p < 0.0001) and miR-125b-2-3p (6.39 ± 0.68-fold change, p < 0.0001) in maternal peripheral blood of the RH-HDFN group compared with the control group.