Barely Significant

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a significant trendp < 0.00010.0× alphagold
Comparison of the staining patterns among patients revealed a significant trend towards increased frequency of DFS pattern (ANA associated diseases 10.4%, JIA 21.7% and nonrheumatic conditions 34.8%, p < 0.0001) and decreased frequency of homogenous staining (ANA associated diseases 34.3%, JIA 26.7% and nonrheumatic conditions 8.9%, p < 0.0001) in nonrheumatic conditions.
highly significantp < 0.00010.0× alphaqualifiedgold
Echocardiography The difference in Group I and Group II was highly significant in terms of both the baseline GLS (-13.37 ± 2.21 vs -19.11 ± 3.4; p < 0.0001) and GLS at 1-year follow-up (-11.23 ± 2.19 vs -13.47 ± 1.84; p < 0.0001).
highly significantp = 0.00010.0× alphaqualifiedgold
5B,C , tumor growth was significantly inhibited by Trametinib exposure (p = 0.0009), while Everolimus-treated tumors did not significantly differ from vehicle control-exposed tumors in either their final size or their growth rate; however, combined treatment with Trametinib and Everolimus resulted in highly significant growth inhibition, as compared to either vehicle control (p = 0.0001) or single agent treatment (p = 0.003 for the comparison between Trametinib and combination; p = 0.0026 for the comparison between Everolimus and combination).
highly significantp > 0.00010.0× alphaqualifiedgold
The exponential increase in rDio3os expression between E and C groups together and separately by developmental stage is highly significant by Chi-square analysis ( p > 0.0001) although the absolute differences in mRNA expression levels between groups are not significant by two-way ANOVA.
highly significantp < 0.00010.0× alphaqualifiedgold
Geographic differences were notable, with the proportion of individuals with probable PTSD ranging from 40.0% to 100% across divisions, yielding a highly significant difference (p < 0.0001), whereas divisions showed minimal variation (Minor vs Majors divisions PR 1.01, 0.64-1.61; p = 0.96); Figure 5 .
highly significantP < 0.00010.0× alphaqualifiedgold
Using RT–qPCR primers that distinguish wild type (WT) and KCNQ2 ∆E5 , we found a highly significant difference, with KCNQ2 ∆E5 detected exclusively in patient samples ( P < 0.0001 adjusting for age, sex and RNA integrity number (RIN); Supplementary Table 2 ), while the levels of WT KCNQ2 transcript were not different ( P = 0.9947 adjusting for age, sex and RIN; Supplementary Table 2 ) (Fig. 2f,g ).