andersonii (tested via independent samples Wilcoxon rank-sum test), while its F is value was also significantly lower ( P < 0.05).Furthermore, verification of Rarefied Allelic Richness (Ar) via the Kruskal-Wallis rank sum test revealed a highly significant difference between the two species (chi-squared = 1770.3, df = 1, P < 2.2e-16), confirming that the genetic diversity of B. andersonii is robustly higher than that of B. tianguii even after standardizing sample sizes ( Figure 3 ). 3.3.
Excerpts
Comparison using a paired t-test for R s from the predictive model and their corresponding permutated variant indicated a highly significant difference between both model types ( p -value < 2.2 × 10 −16 across cases), indicating that these model predictions are extremely unlikely to be due to chance.
The final model was highly significant ( p = 2.2e−16), and for all three cancer types IRF1 was identified as a significant explanatory variable for CD274 expression (Table 1 , left 3 columns).
Additionally, we found 1753 highly significant H2A.Z peaks that were dependent on nrp1-1 nrp2-2 ( p -value < 2.2e-16) (Fig. 3c ).
There exist only small differences in their declared residence area (zip code), but they are older (median age 35 against 24), more likely men (men proportion 62.9% against 49.9%) and live within the Lyon-Villeurbanne urban area (85.3% against 81.7%, all theses differences are highly significant, p-value <2.2*10 −16 ).
Kruskal-Wallis tests revealed a highly significant increase in CNVs in these epithelial tissues compared with the B cells (P<2.2×10 −16 ), indicating that they could be considered tumor cells.
Although circRNA expression shows a clear trend for both positive (β = 1.121, P < 2.2 × 10 −16 ) and negative (β = −1.015, P < 2.2 × 10 −16 ) β values (effect size), there is no such trend in the mRNA expression (β = 0.0294, P = 0.8654; and β = −0.0339, P = 0.8639 for positive and negative β values, respectively).
We observed a highly significant deviation from the expected distribution (Chi-squared test, p < 2.2 × 10 –16 ), indicating strong cell-type-specific expression patterns.
Further, the concordance of miRNA expression (log normalized) of the common miRNAs was also explored by Spearman correlation and showed a highly significant correlation with rho of 0.81, p<2.2x10 -16 ( Fig 4b ).
This test revealed a highly significant difference in the overall distribution ( X-squared = 81.204,df = 4, P -value < 2.2e-16 ).
In contrast, the overall density distribution of 496 protein kinases in the siRNA screen showed a small but highly significant shift ( p < 2.2 × 10 −16 ) towards synthetic lethality with the peak of the density distribution at 0.95 (Fig. 1 c).
1c ), which exhibited highly significant hypomethylation ( P < 2.2e-16; Fig. 1d ).
There is a highly significant overlap in the promoters that gain hmC at 12 hrs and those that lose mC at 72 hrs ( P value < 2.2×10 −16 , Fig. 1d , Supplementary Fig. 6 ).
3C ), with the Kolmogorov-Smirnov test revealing a highly significant difference in the two distributions (p = 2.2×10 −16 ).
Statistical analysis using an independent two-sample t -test (Welch’s correction) revealed a highly significant difference in mean PC1 values between the two groups ( P < 2.2 × 10 −16 ).
The structures look similar but the estimate of the covariate coefficient of the agency effect provided opposite significance results for the F-value (MCMC sample size = 4000): highly significant (p < 2.2e -16 ) vs. not significant (p = .405).
Subsequent statistical analysis revealed a highly significant ( p < 2.2 × 10 −16 ) cell cluster composition between the baseline sample NI Day + 0 ( n = 217 cells) compared to differentiated samples S Day + 15 ( n = 577 cells) and SON Day + 15 ( n = 400 cells) as well as between the differentiated samples ( Figure 3 C, Table S5 ).
The Spearman’s correlation coefficients (ρ) between the positions of the markers on linkage map and physical map were positive (0.996-to-0.999) and highly significant (p-value < 2.2e -16 ), with an average of 0.999 ( Supplementary Table 5 ).
This difference was highly significant ( P < 2.2 × 10 −16 ).
A Chi-square test comparing the observed and expected frequencies of different types of AA combinations gave a highly significant result for data pooled across phyla (X 2 = 255.35, df = 2, P < 2.2×10 −16 , Table 1 ).
A focused analysis of the TCGA-STAD cohort confirmed a highly significant and robust positive correlation between SOX9 and TRAIP mRNA levels (Fig. 2 B, right panel, R = 0.427, p < 2.2e-16).
The 138 c-Jun-regulated genes showed a highly significant 5.8-fold enrichment (p=2.2×10 −16 ) among the 1581 genes regulated during chronic denervation.
The variance of differences for the genomic GC proportion in humans, mice, and fruit flies respectively is σ ^ n 2 = ( 0.000673 , 0.00055 , 0.00103 ) compared to σ ^ r 2 = ( 0.00469 , 0.00552 , 0.0021 ) for the permuted genome sequence, with the ratios being highly significant in all cases (F-test with p-value p < 2.2 e - 16 ).
Single marker analysis revealed that NAL1 _4_31214045 had a highly significant association with tiller number ( p < 2.2 × 10 − 16 ) and explained 22.07% of the phenotypic variance (PVE), while OFP19 _5_15069810 showed a weaker but still significant association ( p = 1.99 × 10 − 5 ), with a PVE of 3.65% (Table 5 ; Fig. 6 A, B).
This is a highly significant (p < 2.2 × 10 −16 ) excess (see Materials and Methods), suggesting some concordance in signal at the individual gene level.