Barely Significant

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highly significantp < 0.0010.0× alphaqualifiedgold
Although the difference in apparent H + affinity between the two concatamers was highly significant (p < 0.001), it was rather slight (0.3 pH units), suggesting that the contribution of individual subunits to apparent H + affinity is not simply additive but that apparent H + affinity is rather determined by the complex interaction of all three subunits.
highly significantp < 0.0010.0× alphaqualifiedgold
The difference in the average CFU values between the TA2-nHP66 group and other two groups was highly significant at all time points (p < 0.001), while there was no statistically difference between the nHP66 group and the debridement only group up to 8 weeks after the debridement surgery ( Fig. 5a ).
highly significantP<0.0010.0× alphaqualifiedgold
Notably, the direct effect of smoking decreased from 0.582 to 0.364 after accounting for mediators, yet remained highly significant (P<0.001), indicating that 62.5% of smoking’s impact operates through pathways not captured by these three mediators—presumably including direct epithelial toxicity, oxidative stress, protease-antiprotease imbalance, and immune dysregulation.