Excerpts

Intriguingly, there was a highly significant region × chromosome interaction ( P = 2.35 × 10 −49 ) effect at the exon-level but not at the transcript-level ( P = 1.00).

Among CpG sites distinguishing current smokers versus never smokers in lung adenocarcinoma at P < 10 −4 (n = 296 sites), we observed highly significant enrichment for the adult blood signature at P = 1.2 × 10 −48 .

Paf1 exhibited highly significant enrichment around the TAD boundaries (p = 4.8E-46) but not replication origins (Figs 7C and S6B ).

Compared with the control group, the differences in muscular layer thickness, the length of pyloric canal and the diameter of pylorus were highly significant (P = 7.44E-44, 3.01E-73, 5.77E-29), and the thickness of mucosal layer remained significant (P = 6.34E-18) (Table 2 ).

4C , NMI and DRAM1 show a highly significant correlative expression with correlation coefficient (CC) of 0.71 and p < 3.7e-042.

There was a highly significant correlation between relative amounts estimated based on OTU counts and on raw reads data (Pearson c = 0.9947; p = 3∙10 −39 ; Supplementary Figure 3 ).

IPA upstream analysis estimated module-specific upstream regulators, including transcription factors (Table S2 ), and suggested that the transcription factor MITF was activated in co-module #12, which was highly significant among co-modules (IPA overlap p-value = 6.91E-39, Fig.

Similarly, Table 4 reveals a highly significant effect of elevation height on PV efficiency (F = 134.21, p = 1.31 × 10– 38 .

The difference was highly significant (Mann–Whitney p = 1.0E–37); (2) location of matching regions: In non-seed-binding miRNAs/isomiRs, we observed that over half of the matching regions began between positions 6 and 8.

Of the four rare variants, two were nonsynonymous to SLC5A10 and were highly significant (rs148178887, p = 1.13 × 10 −36 and rs61741107, p = 8.85 × 10 −56 ).

A highly significant overlap was found with ALI-grown healthy epithelial cells exposed to interleukin (IL) -13 ( GSE37693 ; p = 1.61E-36) and freshly isolated epithelial cells from severe asthmatic patients ( GSE63142 ; p = 1.24E-08) (Fig. 2m ).

The correlation between mean catch-up saccades per second and microsaccades rate was moderate, with a Pearson correlation coefficient of r = 0.58, a 95% confidence interval of [0.51, 0.64], and a highly significant p-value ( p = 1.99e-36).

However, a single SNP on chromosome 9 (at position 20,550,439) was noticeable for its strong and highly significant effect (P = 10 −34 ).

S6 ) and highly significant ( p = 5.1 × 10 −34 , Fischer’s exact test).

The variants (rs16847897 and rs10936599) of telomerase complex showed highly significant association ( p- value = 9.4E-34, OR = 5.04 (3.88–6.55) at 95%CI) with T2D.

Strikingly, ontology analysis resulted in a highly significant enrichment for genes involved in the regulation of insulin transport (hypergeometric test p-value < 10e-33).

When contrasting the associations of α44C and Q between high and low risk subjects, their differences of risk and resistant associations were highly significant (exact Fisher’s p-value = 2.16*10 −31 and 1.92*10 −19 , respectively).

Notably, many of the highly significant GO terms are related to immune function and inflammation such as GO:0002376, immune system process [ P < 1e−30 both comparisons] and GO:0006954, inflammatory response [ P < 1e−30 both comparisons] (Fig. 6 A, Supplemental Table 1 ).

Compared with the control group, combined dcEF + RL stimulation produced a highly significant increase in neurite length ( P = 2.1 × 10−29, η 2 = 0.54).

Pathways showing highly significant results include the MAPK signalling pathway ( p -value = 1.29E-28), the FoxO signalling pathway ( p -value = 8.09E-19), the HIF-1 signalling pathway ( p -value = 9.65E-19), the PI3K-Akt signalling pathway ( p -value = 1.09E-18), and the insulin signalling pathway ( p -value = 2.87E-16).

Sex-related tissue specificity One network specific to histologically normal tissue (Normal: lavenderblush3) featured a highly significant relationship with biological sex (bicor 0.82 P = 3.72 × 10 –28 , n Obs = 113, see Supplementary Fig.

The ANOVA results confirmed that the observed differences in Ct values for COX-IV i1 and COX-IV i2 were highly significant (F(2,83.71) = 132.95, p = 1.04 × 10−26 for COX-IV i1 ; F(2,84.89) = 280.32, p = 4.02 × 10−38 for COX-IV i2 ) (Fig. 3 & Supplementary Fig.

The association of rs4803217 with sustained virological response (defined as absence of detectable HCV RNA in serum at least 24 weeks after discontinuation of treatment) was extremely significant (p = 2.48 ×10 −25 ) in the European-American population ( Table 1 ).

A two-way ANOVA conducted across both cell lines demonstrated a highly significant main effect of drug concentration (F(1,80) = 199.32, p < 1.99e − 23), a significant interaction between formulation and concentration (F(3,80) = 8.01, p < 9.89e − 05), and a significant main effect of formulation type (F(3,80) = 4.08, p = 0.0095), indicating that cytotoxicity is concentration-dependent and formulation-specific, with more pronounced differences observed at higher doses.

When comparing these two gene lists we observed extensive overlap (N = 263) that was calculated to be highly significant (p < 7.130e-23)( Supplementary Table S1 ).