Excerpts

When excluding the same proportion of transcripts as above (57.5%), but considering this time the X chromosome and autosomes separately, the difference of median expression levels between X-linked and autosomal transcripts became highly significant in both sexes (6.82 vs 7.91, P <10 −31 in males; 6.85 vs 7.91, P <10 −30 in females).

Suppression of PAPD4 also led to a highly significant reduction in miRNA expression, (t-test adjusted p value <1×10 −30 ), although the median relative miRNA expression value of 0.71 in siPAPD4 cells was of a smaller magnitude than observed from TUT1 suppression.

Correlations between video tracker drifts and their search coil counterparts were moderate (average vertical ρ = 0.58 ± 0.09; average horizontal ρ = 0.51 ± .09) but highly significant (all p -values < 10 –30 ).

Expression level correlation between milk cell miRNAs and skim milk miRNAs The average miRNA expression levels correlated between MC and SM with a highly significant (p = 4.8 E-30) correlation coefficient of 0.795 ( Fig 2A ).

rs13038305 in Relation to Cystatin C At baseline each copy of the major allele of rs13038305 was associated with a highly significant approximately 0.30 standard deviation (SD) higher plasma concentration of cystatin C both in model 1 (β = 0.33, p = 4.2E-28) and model 2 (β = 0.33, p = 1.7E-29).

The top five ranked interlinked pathways (Supporting Information Table S5 ) and the three Gene ontology (GO) molecular function terms (Supporting Information Table S6 ) are highly significant ( p ≤10 −27 ) with respect to genes differentially expressed after RPL19 knockdown.

Differences between the two groups were highly significant (p = 1.5×10 −27 ).

By contrast, there was a highly significant main effect of dose (p = 3.5 x 10 −26 ), significant genotype*dose interactions (p = 0.007) and significant dose*session interactions (p = 2.0 x 10− 13 ).

Association of FECD grade with TCF4 was highly significant (OR = 6.01 at rs613872; p = 4.8×10 −25 ), and remained significant when adjusted for changes in CCT (OR = 4.84; p = 2.2×10 −16 ).

disease controls were highly significant (P = 3×10 −24 ).

While rs2647044 ( P = 3.85×10 −20 ) was still highly significant, rs9357152 ( P = 7.28×10 −24 ) became the most significantly associated SNP when the effects from the known HLA high-risk genotypes were accounted for in the logistic regression model.

The results were highly significant: p = 1.11 × 10 −23 ( Fig 3A ); p = 5.29 × 10 −16 ( Fig 3B ); p = 3.88 × 10 −5 ( Fig 3D ); p = 1.38 × 10 −16 ( Fig 3E ); p = 1.00 × 10 −9 ( Fig 3F ).

The upstream regions of 17 mid-meiotic internal TSS were found to contain MSE sites ( Table 3 ), an extremely significant enrichment (p<1.5x10 -22 , Fisher's exact test).

There was a highly significant difference between geographical locations in both the allele frequency ( X 2 = 127.7, DF = 11, P-value = 4.97x10 -22 ) and frequency of homozygosity ( X 2 = 142.3, DF = 22, P-value = 1.33x10 -19 ).

Interestingly however, when compared with the HER2+ subgroup only the Georgia set showed a highly significant increase ( p = 6.00 ×10 -22 ) in MMP7 .

This difference is extremely significant with a p-value <1.04×10 −21 .

Highly significant associations for a nonsynonymous SNP (rs12075; G42D ( NP_002027.2 ) ( p = 1.3E-21) and an intronic SNP ( p = 3.6E-13) in DARC on chromosome 1 were identified for MCP-1.

Furthermore, there was however a strong trend in CPD across age groups; cases in the uppermost quantile having a cigarette consumption of 3.2 CPD less than those in the lowest age quantile ( P = 3.01×10 −21 ).

Each of the three possible pairwise regressions were highly significant with p<10 −20 .

As further confirmation of the quality of the model, analysis of variance of cross-validated residuals (CV-ANOVA) for the PLS-DA model was highly significant (p<1x10 -20 ).

The ciliary modules were found to share on average more than 50% of genes with each other, this overlap statistically highly significant (P<10 −20 for the least significant pair of the datasets; see Table S4 for details on the cross-dataset overlap of the modules).

The GCGC haplotype combination of the 2677G>T, 3435C>T, 1249G>A and −24C>T respectively was found to be extremely significant (p = 1.10e−20) with good drug response to CBZ mono-therapy.

Being unmarried was associated with a highly significant increase in the likelihood of smoking (odds ratio = 2.920, 95%CI = 2.3–3.7, P = 8.8E-20).

A linear mixed effects model showed a highly significant effect of disease (F (1,90) = 136.14, p = 1.05e-19) but no significant effect of pathway (F(2,90) = 0.40, p = 0.67), and no significant interaction between pathway and disease (F (2,90) = 0.51, p = 0.60).

The upregulated pathways derived from the gene expression data showed a highly significant overlap with pathways derived from the genotype data (33 of 56 gene sets, hypergeometric P = 1.49×10 –19 ).