Excerpts

Highly significant increases in glutamate were noted in the CEA (p<0.0001) and BLA (p<0.0001; Fig. 6A ).

All correlations are highly significant (p<0,0001***, Spearman).

Highly significant association was found between naive CD4 T cells and CD4+ RTE (all p-values <0.0001).

Correlations of HOMA-IR HOMA-IR was highly significantly and positively correlated with hepatic triglyceride content (r:0.76;p<0.0001), and other less highly significant positive correlations were found with waist circumference (r:0.52;p<0.001), BMI (r:0.48;p<0.01), age (r:0.49;p<0.01) and serum ALT (r:0.3;p<0.03), while inverse correlation with serum adiponectin (r:0.47;p<0,01) and HDL-C (r:0.46;p<0.02) were observed.

Concerning the chronic effects amongst all study days only day 2 showed a highly significant correlation of polynucleosomal with total nucleosomal cfDNA concentrations (r = 0.95; p < 0.0001, Fig 3B ).

On the opposite, there was a highly significant difference between these two tasks concerning the number of characters involved per sentence ( p <0.0001, Table 1 ), in keeping with the social nature of the TOM stimuli.

Age ranged between 2.0 and 5.2 years in the animals from the low-fluoride areas and between 1.6 and 13.3 years in those from the high-fluoride area ( Table 2 ) The difference in bone fluoride concentration between the two groups was highly significant (p < 0.0001), whereas no significant difference existed for age (p = 0.12) ( Table 2 ).

Pooled left and right arm data were then compared between megachiropterans and microchiropterans and showed highly significant differences (T = - 8.77, P = 0.0001); and clear separation of measurements between the groups ( Fig 2C ).

We observed a moderate, but highly significant sensitization of cells after Jarid1A depletion with siRNAs A1+A3 as compared to untransfected (p < 0.0001) and control-transfected (p = 0.0025) cells ( Fig 4 ).

The variance components estimates for genotype and genotype by environment interaction were highly significant ( P < 0.0001) for all locations and across environments ( Table 2 ).

When adjusted for multiple comparisons with Bonferroni's correction (for n = 429 known SNPs), our finding for rs113831133 did not reach statistical significance (required P value <0.0001).

Genetic differentiation between these northern and southern populations was highly significant (Exact test p<0.0001; F ST = 0.15 p<0.0001; R ST = 0.19, p<0.001) and strong population differentiation was also observed for both males (Fisher exact test p<0.0001; F ST = 0.13 P<0.002) and females (Fisher exact test p<0.0001; F ST = 0.11 p<0.003) No first generation migrants between regions were detected by Structure ( Fig 3 ) or Geneclass (100% of the individuals were correctly assigned to their putative population; Quality Index 97.45%).

MVD was positively related to HIF-1α expression in BRCA1-2 carriers (r = 0.521, p = 0.006), and, in particular, we observed a highly significant correlation in the familial group (r = 0.421, p<0.0001).

The model snakes mimicking the snakes found on limestone had significantly greater achromatic and chromatic contrasts on volcanic rocks (achromatic: F 1,15 = 80.13, P <0.0001; chromatic: F 1,15 = 6.930, P = 0.019), while model snakes representing the snakes found on volcanic rock only had significantly greater achromatic contrasts on limestone, however chromatic contrasts was nearing significance (achromatic: F 1,15 = 38.33, P <0.0001; chromatic: F 1,15 = 5.669, P = 0.031).

The difference between these means is highly significant (n = 28; P<0.0001, paired t test, two tailed).

There was a significant trend for increasing test positivity rate by increasing smear grade among the TB contacts for all biomarkers (p<0.0001, Cochran-Armitage test for trend).

Using model estimation of the change in diversity indices associated with 3 months of age we found that the increase in diversity was highly significant for all children as well as those in the case and control groups separately for all diversity indices examined (P <0.0001).

A highly significant dose-dependent inhibition of colony formation (P<0.0001) was also found for MDA-MB-231 breast cancer cells with a similar maximum decrease of 24% (95% c.i.: 10–38) ( Figure 2b ).

There is a highly significant correlation (P<0.0001) between the reduced number of DCs and delay in treatment initiation.

Differences were highly significant (p<0.0001 for medium vs. high, low vs. high and low vs. medium contrasts in paired comparisons).

The correlation between CXR results at autopsy and gross lung PA scores as calculated by non-parametric Spearman's rho (Rs) was strong (Rs = 0.75) and highly significant (p<0.0001) ( Figure 4A ).

Differences in the percentage of eggs hatching over time for the non-sterile and sterile WOL infusions were highly significant ( F = 105.27; df = 5, 40; P <0.0001).

A highly significant decrease in RTP volume by median of 2.1 μl from 33.3 μl in the cold state to 31.2 μl after heating was measured (p<0.0001).

However, due to the extensive variance in fingertip force between the participants across all 13 stimuli, the explained variance was small while still highly significant ( R2 = .062, F (1,257) = 8.49; p < .0001).

A gene set/list was considered as having highly significant overlap and included in further analyses if p<0.0001, p values for the MSigdB analysis were calculated using the hypergeometric test.