Barely Significant

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highly significantP-value = 2.6e -70.0× alphaqualifiedgold
The nuclear ancestry was statistically different between the alleles of seven of the eight SNPs assessed by chi-squared test; m.1438, m.3197, m.4769, m.10398 and m.15043 were statistically highly significant (P-value = 2.6e -7 , 1.34e -6 , 2.45e -7 , 2.2e -16 2.2e -16 respectively) and m.3666 and m15218 were statistically significant (P-value = 0.002 and 0.008 respectively whereas m.9377 was not statistically different.
marginally significantp = 4.38×10 −070.0× alphagold
Interestingly, among the top 25 associations detected, novel genome-wide marginally significant signals outside chromosome 19 were observed: in chromosome 12 (intergenic: rs249153, p = 4.38×10 −07 , OR = 1.41; intergenic: rs249166 and rs249167, both with p = 6.91×10 −07 and OR = 1.40) and in chromosome 5 (intergenic: rs13178362, p = 6.60×10 −07 , OR = 0.75), followed by trends inside the memb
highly significantp = 4.9×10 −70.0× alphaqualifiedgold
Synaptic transmission (SyT) ( Figure 3B , Table 5 ) was a highly significant sub-family of nervous system development and function (34 molecules, 23.3% of parent function; p = 4.9×10 −7 ) sharing 10 common genes with Ngs ( CNR1 , SHC3 , NLGN1 , ADRB2 , CACNA1A , CNP , and MPZ were elevated and TNF , FGF2 , and IL1B were suppressed by FD).
highly significantp = 5.07e-070.0× alphaqualifiedgold
When analyzing the results by APL1A allele, only the APL1A 2 allele displayed a consistent protective effect, because the global silencing of all APL1A alleles caused a highly significant increase of infection prevalence only among carriers of the APL1A 2 allele ( p = 5.07e-07; Table 1 ).
highly significantp-value = 6.278e-070.0× alphaqualifiedgold
Even though there were highly significant differences between the cfDNA of healthy and breast cancers (p-value = 6.278e-07) and healthy and ovarian cancers (p-value = 2.708e-11), on the individual levels there were many overlapping cfDNA values between cancer-free individuals and cancer patients.
highly significantp = 8.7×10 −70.0× alphaqualifiedgold
The correlation between the percentages of CD27 low IFN-γ + cells and the form of lung pathology was highly significant (r = 0.63, p = 8.7×10 −7 ), but it was likely secondary to lung destruction: it appeared only when higher scores were assigned to more destructive TB forms (i.e., tuberculoma – score 1; TB infiltrate – score 2; cavitary TB – score 3; caseous pneumonia – score 4); within a group of patients with the same form of lung TB pathology (e.g., TB infiltrate) the percentages of CD27 low IFN-γ + cells correlated with lung destruction (r = 0.45, p<0.01).
highly significantP<10 −60.0× alphaqualifiedgold
By the least stringent definition of a seed match – a six-nucleotide match complementary to nucleotides (nt) 2–7 or nt 3–8 in the miRNA – 70% of the miR-1 targets and 75% of the miR-124 targets possessed seed matches, a highly significant (P<10 −6 and <10 −25 , hypergeometric density distribution) enrichment over would be expected by chance ( Table 1 , designated ‘6mer’ seed match).