Excerpts

The correlation between lineage and average sperm length for all 33 males was highly significant (r = -0.811, n = 33, t 31 = 7.71, p = 1.1E-8).

For example, of the 559 genes in the Chen androgen signature (448 of which were represented in at least three prostate tumor datasets), 29 were correlated ( p <0.05) with KLK3 in at least three out of the four prostate tumor datasets; by chance, nine were expected, and so the amount of actual overlap was quite significant ( p = 1.2E-08).

Analysis of the strain differences produced highly significant results using both ANOVA and the non-parametric Kruskal-Wallis test (p-value = 1.25×10 −8 and 2.37×10 −5 , respectively).

There was a highly significant positive relationship between tissue 13 C and 15 N for pitchers harvested 3-h after receiving U-Phe at both Fort Albany ( P = 1.28×10 −8 ; Fig. 3C ) and Tom Swamp ( P = 7.17×10 −8 ; Fig. 3D ).

For this list of 1409 DETs unique to the ASD GI ileal biopsies, the Diseases and Disorders category returned highly significant associations with: (1) gastrointestinal disease [217 genes; p = 1.4×10 −08 ] including inflammatory bowel disease [42 genes; p = 3.2×10 −05 ] and colitis [25 genes; p = 8,8×10 −04 ] and (2) inflammatory response [198 genes; p = 3.8×10 −07 ] including inflammation of organ [88 genes; p = 3.8×10 −7 ], antibody response [27 genes; p = 2.1×10 −6 ] and activation of leukocytes [74 genes; p = 4.9×10 −6 ].

Similarly, the same four variables were also highly significant independent predictors of eGFR decline (defined as 50% reduction from the baseline eGFR) in our cohort (Model 2): baseline eGFR [HR = 0.98, 95% CI 0.98–0.99, p = 1.6*10 −8 ], serum albumin [HR = 0.46, 95% CI 0.35–0.62, p = 2.7*10 −7 ], hemoglobin [HR = 0.81, 95% CI 0.75–0.89, p = 1.5*10 −6 ], and SBP [HR = 1.02, 95% CI 1.00–1.03, p = 6.4*10 −3 ].

The BP GO term “response to toxic substance” was highly significant too (16 genes among the top 65; P-value = 1.72e-08), followed close by the more general term “cellular response to chemical stimulus” to which half the genes were related (40 genes of top 88; P-value = 1.41e-07).

The p -value of the SNP associated with E1 was highly significant in the two collections: p = 1.83E-08 in the core collection and p = 1.21E-11 in the total collection.

One marker (rs885036, position 98671226) on chromosome 2q12 showed a highly significant interaction with treatment arm (P = 2.17x10 -8 ).

Both changes were highly significant (student’s t-test, p<2.3900e-8 for rHIgM22 vs isotype control; p = 0.0000 for PDGF/FGF-2 vs isotype control).

A highly significant interaction was seen between time and age (p = 2.6e-08).

We observed a nominally significant finding (p = 2.9E-08, λ = 1.027 - corrected p gc = 2.2E-07, λ = 1.0015) on chromosome 6q21 in the gene coding for the non-receptor protein-tyrosine kinase, Fyn.

In the sub-Saharan African sample, both the MAF and the DAF spectra showed a highly significant increase in the proportion of singletons with respect to the proportion expected under a constant population size model (χ 2 P = 3×10 −8 and χ 2 P = 9×10 −5 , respectively).

Analysis of variance indicated a highly significant genotype effect for both traits (p = 3.02 × 10 − 8 for LD; p = 2.04 × 10 − 4 for Survival%).

The same markers at MITF on CFA20 and USH2A on CFA38 were detected as marginally significant when both herding and non-herding breeds were analyzed together ( P = 3.5 x 10 −8 and P = 3.6 x 10 −8 , respectively).

Here, we expect 70 genes and find 118- the actual number of genes in the overlap exceeds that expected by chance and was highly significant (p = 3.6 -8 , binomial test).

There was low between-study heterogeneity ( I 2 =32·8%: p =0·13), and the overall association of short sleep with diabetes risk was highly significant (OR=1·33 [95%CI: 1·20, 1·48); p =4x10 -8 ), with no evidence of publication bias (Egger’s test p =0·15).

Three SNPs were highly significant ( p < 5 × 10 −8 ): rs651821 , rs6494835 and rs8035009 ( Fig 2 ).

In the current study, a highly significant association was observed between the frequency of IL4 −590 SNP in 98 individuals allergic to D. pteronyssinus and 116 controls and the T/C genotype (p = 0.000000052) and the C allele (p = 0.010), suggesting a protective effect against sensitization to dust mites.

When the NAFLD phenotype was defined by ALT-threshold + dyslipidemia (ALT2DL, S6c Table in S1 File ), the association was highly significant in participants of EU ancestry (OR 1.05, P = 6.5x10 -8 ) as well as in the trans-ethnic meta-analysis (OR 1.05, P = 7 x 6.5x10 -9 ).

Meta-analysis of two independent Japanese datasets demonstrated a marginally significant association of SNP rs7301743 in TBX3|MED13L with a 0.071 mV (95% CI, 0.038–0.11 mV) shorter R wave amplitude in the V5 lead per minor allele copy (P = 7.635 x 10 −8 ).

We observed a highly significant association of SNP rs7301743 in TBX3|MED13L with a 0.071 mV (95% CI, 0.038–0.11 mV) smaller voltage of the R wave in V5 per minor allele copy (P = 7.635 X 10 −8 ).

Although subjects differed in their use of the full scale of possible bid values ( Figure 2A ), their preference data was well-described by a logistic regression: a one-sample t-test on the sensitivity of like responses on bid value was highly significant (t(16) = 9.2, p = 9×10 −8 ).

3.1 Apoptosis in CD8 + T lymphocytes correlates with systemic iron levels In general, a highly significant difference was found between the CD4 + and CD8 + T-lymphocyte subpopulations in terms of the percentages of apoptotic cells (T Test p = 9.4x10 -8 , KS-Test p = 0.000002), with the average apoptosis percentage being 21.8% ±9.9% in CD4 + T cells, and 47.3% ±21.8% in CD8 + T cells.

Statistical analysis carried out on the timing errors, pooled over all subjects after averaging over all repetitions of each condition (four-way ANOVA, 3 [viewing distance] x 5 [ball descent duration] x 2 [figure type] x 6 [character type]), showed highly significant effects of character type ( F 5,1168 = 113.188, P <10 −7 ) and figure type ( static versus dynamic , F 1,1168 = 25.180, P <10 −6 ), less significant effects of viewing distance ( F 2,1168 = 3.602, P <0.05) and of the interaction between character type and figure type ( F 5,1168 = 2.569, P <0.05).