Excerpts

One-way ANOVA showed a highly significant difference among time points (p = 8.79 × 10 − 11).

A t-test comparing the means returns a p-value of 0.167 (no significant difference) while a 2 sample KS-test returns a highly significant (p-value <10 −10 ) difference between the two distributions.

This difference is highly significant (P<10 −10 , Mann-Whitney U-test, n = 100) [59] .

This represented a highly significant overall decline in the inheritance of BMI with increasing exercise (P<10 −10 ).

Post-hoc t-tests showed a highly significant difference between FM (mean number of trials = 37.12; s.d. = 7.3) and FH (mean number of trials = 5.5; s.d. = 2.37) (t 16 = 14.94, P <10 −10 ).

To further explore this relationship, we preformed a linear regression for Tup1 binding by the number of recruiter proteins bound and discovered a highly significant regression of R 2 = 0.500 (P<1×10 −10 ) ( Figure 2D ) .

Both correlations were extremely significant (p<10 −10 ).

In these studies, a highly significant ( P <1×10 −10 ) association was detected for CDKAL1 , in accordance with the present study in Japanese.

Furthermore, highly significant enrichments in biological functions have been observed to be related to the immune system; for example, Inflammatory Response (p<1.15E10 −16 –2.06E10 −4 ), Immunological Disease (p<1.11E10 −11 –1.98E10 −4 ), Hematopoiesis (p<7.52E10 −28 –2.91E10 −4 ) and Cell-mediated Immune Response (p<5.87E10 −27 –2.62E10 −4 ) were frequently encountered.

The evidence for directed migration is further supported by a highly significant Rayleigh test (p = 1.32×10 −10 ) demonstrating a unimodal deviation from uniformity or random migration in this instance.

The decrease in TLC in overweight patients was mainly due to a decrease in expiratory reserve volume (ERV) further illustrated by a highly significant ( p = 1.33×10 −10 ) correlation between BMI and ERV.

The likelihood-ratio test gave a highly significant result (likelihood-ratio statistic was 48.22149, P = 1.9 e-10).

In the case of the consistently down-regulated TFs we found one highly significant model ( P ≤1.99×10 −10 ) composed of six elements corresponding to TFBS for E2FF, RXRF (Retinoid × receptor heterodimer-binding sites), KLFS (Kruppel-like factors) and ZF02 (C2H2 zinc finger transcription factors 2).

A multivariate, ANOVA-type analysis showed that time was a highly significant factor for lesion severity ( P = 2.29x10 -10 ).

A formal test of independence performed on the multi-way contingency table was highly significant (Chisq = 40.1, df = 1, p -value = 2.374e-10), revealing very strong associations between certain variables (Phi-Coefficient = 0.811), as graphically depicted in the association plot presented in Fig 6 .

We found a highly significant correlation between the number of GT n repeats in intron 2 of the TLR2 gene and the polymorphism Arg753Gln (rs5743708) (r = 0.0099038, P = 2.76 × 10 −10 ) (see S1 Fig ).

The log-rank test comparing the overall survival of the two groups was highly significant ( P ≤2.8E-10, Figure 2A ).

GWAS Genome wide association analyses of IL-10 levels ( S3 Table ) resulted in one highly significant peak on chromosome 9 in the ACS patient cohort (top SNP: rs676457, P = 4.44*10 −10 ), and another borderline significant SNP on chromosome 6 in the healthy controls (rs11961593, P = 1.80 × 10 −7 ) ( Fig 1 ).

A direct comparison between neighbors of the multipliers in the times table vs numerical neighbors to the response in the number line showed that the former were much more frequent, a highly significant result as revealed by a chi-squared test (p<5.29e-010) ( Fig 8A ). 6.

Differences in the extent of linkage disequilibrium were highly significant (p<6.2×10 −10 ) for all population pairs except Germans and British ( Fig. 7 ): LD was highest in Eastern Finns and lowest in Germans and British.

Similarly, the interactions between the two fruit fly species and the temperature regimes were found to be highly significant for adult fecundity (F = 11.85; d.f. = 5, 168; P = 7.97x10 -10 ).

Moreover, the probability of a right-handed turn (given hereafter as π) based on the GLM was 0.621, a highly significant difference (p = 8.2×10 −10 ) from that expected for random turning (π = 0.5).

The differential expression in RC disease between these 261 target genes and all non-target genes was highly significant (p = 8.8×10 −10 in muscle and p = 5.5×10 −35 in FCLs) ( Fig.

When the Class II and Class III SNPs were included in the logistic regression model, the rs4959039 SNP retained a highly significant association with MS susceptibility ( p = 9.70×10 −10 , odds ratio = 1.52).

Sets of 1,049 and 969 genes (out of the total of 14,405 represented on the microarray), were found to be modulated in hippocampus and cortex, respectively, the intersection of the two sets consisting of 619 genes, a highly significant number (P<10 −9 ) ( Figure 5A ).