Excerpts

The main frequency effect was highly significant ( F 3,24 = 41.10, P < 0.0001).

The difference between the vaccine and control group at D28 is highly significant ( P <0.0001).

The 19/24 published experiments with moderate, strong, or total loss of binding all showed highly significant ( P < 10 −4 ) negative contrast differences.

Aggregating results from several large-scale cis-eQTL studies across tissues 9 , 34 , we found that 12 of the 59 of the (enrichment p value = 2.8 × 10 −05 ) novel genes have nominally significant ( p value <1 × 10 −04 ) evidence of cis-regulatory SNPs to be associated with SCZ or other different neuropsychiatric diseases.

The difference between one- and two-talker conditions was highly significant for both groups ( Z = 4.87, p < 0.0001 for Boston, Z = 4.22, p < 0.0001 for Tsimane’, Wilcoxon signed-rank test); when expressed as sensitivity, Boston participants achieved a mean d -prime of 4.27, and Tsimane’ participants achieved a mean d -prime of 3.23.

6c ) Stratified by 30-day survival, we found a highly significant correlation between LRT neutrophil elastase and galectin-3 in survivors only (Fig. 6d, r = 0.54, p < 0.0001), an effect that was also driven primarily by patients with ARDS, as well as patients classified to the hypoinflammatory subphenotype (Fig. 6e–f ).

1a ), supra-threshold amplitudes of wave I of the ABR (in response to 50-μs clicks) remained low and showed significantly shallower growth with sound intensity, compared to pre-exposure values (repeated measures analysis of variance (ANOVA) for pre-exposure and 4-week post-exposure data showed a significant effect of group, p = 0.043, and a highly significant interaction between time of measurement and sound intensity, p = 0.0001; Fig. 1b ).

The p-value indicates highly significant **** p < 0.0001 while p > 0.05 is considered not significant.

Although the interaction was not significant, post hoc simple effect analyses confirmed that the aforementioned trend was highly significant in prefrontal cells (simple effect of cycle, F 3, 2244 = 11.3, P < 10 −4 ), with inferior parietal cells showing a similar but more moderate trend ( F 3, 2244 = 3.32, P = 0.02).

In replicated hydroponic experiments showing highly significant differences in seminal root length ( P < 0.0001) between 1RS and 1RW, we analyzed the aerial part of the plants.

In addition, all measurements of Q A redox state and g s in all lines could be described by a single highly significant positive correlation ( P < 0.0001, ANOVA; Fig. 1h ), consistent with a role for Q A redox state as an early determinant for stomatal opening in response to light intensity 17 .

Aligned rank transform three-way ANOVA analysis revealed significant effects of session and experimental day, and further demonstrated a highly significant interaction between group (TMP versus vehicle) and session (A, D, A*; P = 1.3 × 10 −4 ), indicating that cell ablation significantly but differentially affected learning in novel and familiar sessions (Fig. 5e ).

Disease had a highly significant ( p = 0.00017) impact on cell composition and steroid use was marginally significant ( p = 0.04680).

These loci were only nominally significant in the analysis including the svPPA patients ( LRP1B : P = 1.72 × 10 −4 ; OR = 4.66, COL22A1 : P = 0.03; OR = 5.32; TMEM135 : P = 1.68 × 10 −3 ; OR = 2.19, and TRPC4 P = 1.25 × 10 −4 ; OR = 2.91).

Reassuringly, the association with a clinical diagnosis of “vitamin D deficiency” (ICD-10 E55; N cases = 3150, N noncases = 344,619) was negative and nominally significant (i.e., higher DBP associated with a reduced risk of a clinical diagnosis of vitamin D deficiency; beta = −0.07, standard error = 0.02, P value < 1.9 × 10 −4 ).

These correlations were highly significant ( p < 1.96 × 10 − 4 ).

A pairwise combined microCT and gas exchange analysis of the four Arabidopsis lines revealed a highly significant positive correlation of g s and palisade porosity (Pearson correlation, r 2 = 0.471, P = 0.0002; Fig. 5l ), with the focl-1 mutant data grouping below those for the Col-0 control and on a par with the EPF2OE samples.

The correlation between the number of BS and gene transcription levels was markedly significant (Supplementary Fig. 10c , p = 0.0002; Pearson correlation analysis).

1b ) revealed highly significant correlations of PC1 and PC2 with hepatic zones (PC1: r = 0.47, p = 2.0 × 10 −4 ; PC2: r = 0.86, p < 2.2 × 10 −16 , Supplementary Figure 3) indicating zonation as a major driver of variation between samples.

A Fisher's combined probability test revealed a significant trend for the five inactive female comparisons to agree with the results of the active female assays ( χ 2 10 =34.2, P =0.0002).

The difference among body mass distributions of extinct, introduced, and remaining frugivore species was highly significant (ANOVA, F 37,2 = 10.343, p = 0.00027; Kruskal–Wallis Χ 2 = 16.477, p = 0.00026, see Supplementary Fig. 1 ).

However, when we performed mediation analysis, conditioning on the expression of TOP2B , the association between CX-5461 IC 50 and MYCN expression was lost ( P = 0.8), but TOP2B remained highly significant ( P = 2.7 × 10 −4 ), suggesting that the association between MYCN and CX-5461 IC 50 was mediated through MYCN ’s effect on TOP2B expression.

Variants in MT-CYB were nominally significant (p = 0.0003): MT-CYB (mitochondrial cytochrome b) is part of the mitochondrial respiratory chain, and essential for Complex III formation.

We also observed a nominally significant eQTL association within the same region of the ABO gene (Supplementary Fig. 2b ) at baseline (eQTL association signal for rs630510, p = 3.0 × 10 −4 in moderate LD r 2 = 0.27 with rs495828 pQTL SNP).

Depletion of SD1 showed a non-significant 1.07-fold fall ( p = 0.1815) in neutralization titers to Victoria, but a highly significant 1.9-fold fall in titers to XBB.1.5 ( p = 0.0003) (Fig. 5b ).