Hence, when looking specifically at peritumoral tumor cell clusters as a surrogate of glial migration and infiltration, the average results between control condition (8 animals) and all chemokine groups were highly significant: CXCL10 (7 animals): 37 vs. 7 ( p < 0.0001), CCL2 (9 animals): 37 vs. 28 ( p = 0.0258), CCL11 (8 animals): 37 vs. 25 ( p = 0.0003) and the combination (7 animals): 37 vs. 24 ( p = 0.0070) ( Figure 3 D). 2.2.2.
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Degrees of significance were assessed by three different rating values: * p 0.05 (significant), ** p 0.01 (highly significant), *** p 0.001 (extremely significant), and **** p ≤ 0.0001 (extremely significant) or non-significant ( p 0.05). 5.
Concerning p -values, the results were highly significant for the protein when stored at 4 °C for all the tested conditions ( p -value < 0.0001), and significant when the protein was stored at −80 °C ( p -value < 0.05 and p -value < 0.01).
[ 54 ] compared 75 patients with cervical lesions (mostly squamous cell carcinoma and adenocarcinoma) against 49 healthy volunteers, finding that the APT values of cervical cancer and normal cervical stroma showed highly significant differences ( p < 0.0001).
In contrast to that, upon additional expressing of Jv, a highly significant increase ( p < 0.0001) in ectopic actin bundle length (16.1 ± 3.4 μm) and width (0.47 ± 0.01 μm) was evident ( Figure 1 E, Table 2 ).
Correlation between Serum Mg Concentration and Isotopic Composition There is a lack of significant correlation between the serum Mg concentration and isotopic composition in all but one dataset between the present study and Grigoryan et al.—the exception being the T1DM group from Grigoryan et al., in which a highly significant inverse correlation was observed ( r = −0.70, p < 0.0001) ( Figure 4 ) [ 25 ].
Both 1 μg/mL and 5 μg/mL treatments led to a highly significant increase compared to untreated controls ( p < 0.0001) ( Figure 4 D).
Patients with smaller deletions (≤0.25 Mb) had a mean GFAP score of 73.98 ± 45.7, compared to 108.34 ± 40.67 in those with deletions >0.25 Mb, demonstrating a highly significant statistical difference ( p < 0.0001).
However, over time, the exercise speed of bves KO zebrafish significantly decreased, showing a highly significant difference compared to WT zebrafish ( Figure 3 D, p < 0.0001).
In Group I, glycerophospholipid metabolism exhibited highly significant differences ( p < 0.0001), and significant differences in ether lipid metabolism, vitamin digestion and absorption, and fat digestion and absorption ( p < 0.05, Figure 2 g).
All the main and interaction effects were observed to be highly significant ( p < 0.0001).
Indeed, a highly significant decrease ( p < 0.0001) in BV/TV was noted at the distal femur following maternal exposure to Cd during pregnancy and lactation compared to the control group and Zn group ( p < 0.01).
S100B showed a highly significant ( p < 0.0001) upregulation in the treated hypoxia group (2.114 ± 0.7348) compared to the control group (0.4455 ± 0.1956), whereas the untreated hypoxia group (0.8149 ± 0.4930) was similar to the control group (0.4455 ± 0.1956).
On the other hand, podocyte damage groups (MCD, FSGS, MGN and amyloidosis) showed a statistically highly significant upregulation of podocyte CD73 ( p < 0.0001); the significant increase was consistent also when comparing single entities with negative controls ( p at least < 0.001).
Figure 10 shows that the control group had a glomerular mesangial mean area of 3219.3 μm 2 , while rats with DN had a mean of 5659.7 μm 2 , which is a highly significant difference (**** p < 0.0001).
In contrast, longitudinal within-subject analysis revealed a highly significant upregulation in miR-146a-5p expression from T0 to T2 in both sexes ( p < 0.0001).
GDF-15 showed the most robust response, with highly significant main effects for both time and dose and a strong interaction ( p < 0.0001).
In fact, cosinor periodogram revealed that below 74 years the rhythm was not statistically significant neither for Clock and Per1 ( p > 0.17 and 0.37 respectively) although above 74 years it was highly significant for the three genes ( p < 0.0001).
The ANOVA results for the set (i) showed highly significant and statistically greater Ks in the set of 26 mitogenomes: Ks = 1.618 ± 0.019, Ka = 0.384 ± 0.019 ( n = 325), F = 1949.2, d.f. = 1; 648, p < 0.0001 (effective hypothesis decomposition).
For both HA and NA, the correlation between the indexes was extremely significant ( p < 0.0001).
This was a highly significant difference ( p < 0.0001) compared to the age-matched hSOD1-WT mice ( Figure 6 B).
There was also a highly significant ( p < 0.0001) effect of temperature on cytoplasmic ROS levels after 6 and 12 h IVM.
Using DBS, the upstream control element (UCE) and core promoter (CP) region as well as the 5′ external transcribed spacer (ETS) showed highly significant correlations between methylation and age (UCE/CP ρ = 0.68; p < 0.0001 and ETS ρ = 0.60, p < 0.0001) ( Figure S1B ).
This was highly significant ( p < 0.0001; Figure 3 c).
Following a 24 h exposure period, both cell models showed a highly significant response to the compound ( p < 0.0001) at 2.0–5.0 μM, with non-significant responses at 1 μM.