Excerpts

A linear regressing analysis was also performed on the data from the HT assay and AHT device ( Figure 3 B), which demonstrated a highly significant correlation coefficient close to one ( R 2 = 0.998, p < 0.0001).

The statistical difference was highly significant for both LVIDDn (Kruskal–Wallis test, p < 0.0001) and LA/Ao (Kruskal–Wallis test, p < 0.0001).

The fixation indices showed that genetic differentiation at all the three hierarchical levels were highly significant ( Fst = 0.276, Fct = 0.0969, and Fsc = 0.199, p < 0.0001). 2.2.

A highly significant impairment of cell viability, corresponding to a 74% reduction compared to the untreated cells ( p < 0.0001), was observed in 100 μM H 2 O 2 -treated cells, in agreement with the study of Ghaffari et al.

ANOVA indicated that the model was highly significant ( p < 0.0001) with an insignificant lack of fit ( p = 0.3319 > 0.05), demonstrating good overall fitness.

magna was higher than that in other stages ( Figure 2 ), and the expression of EmSAG10 (p < 0.0001) and EmSAG11 (p < 0.0001) in the merozoite stage was higher than that in the other stages ( Figure 2 ), the difference was extremely significant ( p < 0.0001). 2.4.

Once again, highly significant differences ( Table S6 ) were detected in the colon levels of LTB4 at the different time points ( p < 0.0001 for no DSS vs. 5 days of DSS treatment; p < 0.0001 for 5 days DSS treatment vs. 10 days after DSS removal).

The non-parametric one way ANOVA of prediction scores distribution among categories was highly significant for all three metapredictors ( p < 0.0001 for all predictors with VEST3 Kruskal-Wallis statistic K = 156.1, REVEL Kruskal-Wallis statistic K = 113, ClinPred Kruskal-Wallis statistic K = 168).

For both HA and NA, the correlation between the indexes was extremely significant ( p < 0.0001).

Standard resazurin-based drug sensitivity assays showed that as expected, TbAT1 expression caused a highly significant sensitization to tubercidin ( p < 0.0001) in three independent clones ( Figure 10 ), as tubercidin is a good substrate of TbAT1/P2 [ 46 ] but at best a poor substrate for the T. congolense adenosine transporter, TcoAT1 ( Table 6 ) and as a result tubercidin is a relatively poor agent against T. congolense ( Table 8 ). 2.4.4.

All regressions were highly significant ( F -value = 352.31, and p -value < 0.0001 for CLD % and F -value = 276.91, and p -value < 0.0036 for TS), and also the R 2 coefficients were adequate (0.988 for CLD %, and 0.998 for TS), demonstrating the models are suitable for representing the responses.

There was also a highly significant ( p < 0.0001) effect of temperature on cytoplasmic ROS levels after 6 and 12 h IVM.

Patients with smaller deletions (≤0.25 Mb) had a mean GFAP score of 73.98 ± 45.7, compared to 108.34 ± 40.67 in those with deletions >0.25 Mb, demonstrating a highly significant statistical difference ( p < 0.0001).

This trend was progressively accentuated at weeks 8 and 12 (W8, W12), when the differences between DM+ and DM– were highly significant ( p < 0.0001).

ASA concentrations > 1000 μM (10,000 μM and 16,000 μM) impaired the mitochondrial metabolic activity, which is equivalent to aerobic cellular respiration, revealing highly significant differences in comparison to the remaining concentrations after 3 (16,000 μM: p < 0.0001–0.01) and 7 (10,000 μM and 16,000 μM: p < 0.0001) days of cell culture with a visible decrease in their respective RFUs.

A meta-analysis based mainly on the findings of six studies pertaining to treatment with clozapine supported a significant overall beneficial effect on suicidal behavior, with a highly significant ( p < 0.0001), 3.3-fold [CI: 1.7–5.7] lower pooled risk of suicidal behaviors with clozapine compared to alternative treatments [ 41 ].

In the 41 individuals identified as hatchery descendants ( Table 5 ), this frequency (*90 allele) was very much smaller ( q = 0.036), being the difference between this and the frequency of the whole pool of hatchery samples highly significant (Chi-Square of 37.95, 1 d.f., p < 0.0001).

The fungal species factor showed a highly significant effect (SS = 102,747.0; df = 2; MS = 51,373.4; F = 7730.34; p < 0.0001), indicating substantial differences in growth among the three fungal species evaluated.

Treatment with haloperidol increased the lysosomal pH in a dose-dependent manner, an effect that was highly significant ( p < 0.0001) with doses of 10 (6.56 ± 0.24, mean ± SEM, n = 15) and 25 μM (8.18 ± 1.46), but not with 5 μM (4.21 ± 0.41) ( Figure 2 ).

A highly significant association also existed between the number of circulating aPMPs and CDAI ( p < 0.0001) ( Figure 2 g).

When all samples were divided into IDH1 gene mutated ( IDH1mut , n = 18) and IDH1 wild-type ( IDH1wt , n = 78) gliomas, we observed a tendency of lower expression of CASC2 in IDH1wt ( p = 0.053) and highly significant relationship between higher miR-21 expression and IDH1wt gliomas ( p < 0.0001) ( Figure 2 A,B). 2.3.

In contrast, the LGG cohort showed highly significant separation of survival curves, with the low-risk group demonstrating markedly improved outcomes ( p < 0.0001) ( Figure S3E ).

Differences were considered significant at various p -values: p > 0.050 was considered non-significant, p < 0.050 (*) was significant, p < 0.010 (**) was very significant, p < 0.001 (***) was highly significant and p < 0.0001 (****) was extremely significant. 5.

The differences across these groups were highly significant ( p < 0.0001), indicating a positive correlation between MIF levels and disease severity.

Of the 80 SNPs, two were identified exhibiting highly significant LD ( p < 0.0001; D’ > 0.95, r 2 > 0.85) with rs35286811 (i.e., rs72798738 and rs11678584 ( Table 4 , Figure A1 )), and for each of these, as for rs35286811, the minor allele was the risk allele.