Excerpts

The difference was highly significant ( p < 2.2 × 10 −16 ), indicating robust epigenetic dysregulation of the SYTL4 locus in breast cancer ( Figure 2 A).

A total of 190,678 gene pairs had at least one TSG, and the difference in p -values between pairs with TSGs and with no TSGs was highly significant ( Figure 3 , Wilcox rank-sum test p -value < 2.2 × 10 –16 ).

This comparison resulted in 196 common antigens out of 481, a highly significant overlap (odds ratio: 6.4088; 95% CI: 5.3011–7.7479; chi 2 p -value < 2.2 × 10 −16 ).

This polymorphism showed a highly significant risk effect on fibrogenesis, with an OR of 9.2 in the NAFLD/MASLD cohort ( p = 2.7 × 10 −14 ) [ 13 ].

This difference was further confirmed by a Mann–Whitney U test with continuity correction, which demonstrated a highly significant difference in absorbance distributions between the two strains ( W = 36,316, p = 2.846 × 10 −14 ).

Statistical analysis using a two-sample t -test assuming equal variances revealed highly significant differences: SMRmut vs. #61 ( p < 1.47 × 10 −13 ), SMRmut vs. #62 ( p < 1.45 × 10 −13 ), and SMRmut vs.

Here, MDA-MB-231-BR CM significantly upregulated CXCL1 ( p = 0.0001) and almost significantly downregulated the TXNIP gene level ( p = 6.788 × 10 −12 ) in hBMECs in comparison to MDA-MB-231 CM.

On the contrary, palmitoleic acid showed several highly significant correlations with anthropometric features (BMI: r = 0.408, p = 3.5 × 10 −11 ; waist/height ratio, fat mass: r = 0.402, p = 3.35 × 10 −10 , fat-free mass) and with systolic (SBP) and diastolic BP (DBP).

A multifactorial ANOVA of the three independent factors on OC concentration determined that all the factors (water content (WC), pH, and time) had highly significant effects ( p = 7.00 ×10 −11 ; p = 7.13 ×10 −5 and p = 7.97 × 10 −6 , respectively), but none of the interactions between the factors were statistically significant, indicating no combined effects on OC concentration in the extracts.

The top four most enriched terms among upregulated genes were extremely significant, with a p -value < 10 −10 .

Pairwise group comparisons using Fisher’s exact test revealed a highly significant difference in the morphology of EVs between patients with GBA1-PD carrying the p.L444P and p.N370S mutations ( p = 1.37 × 10 −9 ).

In support of that notion, we compared the predicted MaxEnt and U2AF35 scores for BRCA2 and VARS2 -derived sequences corresponding to our model 3′ss (but mutated to all possible variants in the exonic part) and found a highly significant correlation between these two scores (r = 0.658 and p = 3.4 × 10 −9 for BRCA2 ; r = 0.573 and p = 7.5 × 10 −7 for VARS2 ) ( Figure S2 ; Table S2 ).

421.33 ± 8.80 pg/mL, respectively, and the difference remained highly significant after adjustment for age and sex ( p = 1.14 × 10 −8 ).

Kolmogorov–Smirnov test shows that the delay in developmental time for Ly4 in aged human subjects is highly significant ( p = 1.89 × 10 −8 ) [ 39 ].

The results show that TPSA is quite significant ( p -value = 4.1 × 10 − 8 ).

As SMR is based on highly significant eQTLs ( p < 5 × 10 −8 ), this constitutes an additive value for using eQTLGen by providing more power to detect regulatory associations.

The difference on the aggregated confusion matrix of all models of these three pathogens was highly significant ( p -value = 5.6 × 10 −8 , McNemar’s test).

In line with the elevated S-ASM activities in patients, we have found strong and highly significant correlations of S-ASM with these liver enzyme activities (Rho > 0.37 and p < 6 × 10 −8 for all three enzymes, Table 2 , Figure 3 ).

The median mutation count was lower in the H/L cohort compared to the NHW cohort, with a highly significant p -value ( p = 1.02 × 10 −7 ), suggesting potential differences in genomic instability between these populations.

Activity An RM-ANOVA revealed highly significant effects for both treatment (F(7, 48) = 9.66; p = 1.95 × 10 −7 ) and the interaction between treatment and time (F(35, 240) = 2.68; p = 5.61 × 10 −6 ) on locomotor activity (LMA), as defined in the Methods section.

The association between p57 negativity and CHMs was highly significant (χ 2 = 26.94, p = 2.1 × 10 −7 ; Fisher’s exact p < 2 × 10 −7 ).

This identified 82 significantly enriched GO terms ( Table S3 ) spanning broad aspects of plant biology, of which the top 25 Biological Process terms are presented in Figure 3 A, including highly significant categories such as cellular process (GO:0009987; adjusted p = 3.6 × 10 −7 ), metabolic process (GO:0008152; adjusted p = 9.9 × 10 −6 ), biological process (GO:0008150; adjusted p = 1.3 × 10 −5 ), and cellular metabolic process (GO:0044237; adjusted p = 2.0 × 10 −4 ).

The poor survival by high fetuin-A expressing tumor cells was highly significant in poorly differentiated gastric tumor cells (overall survival log rank P = 3.6 × 10 -7 ) [ 60 ].

The differences in FB-E miR-9 levels between the EtOH and control groups were highly significant ( p = 0.000000464825; Figure 6 A). *** p < 0.001.

The combined allelic test was highly significant, with p = 5.0 × 10(-7).