Excerpts

Among these pairs, four exhibited highly significant values ( p = 0.0000 +/− 0.000), which are highlighted in bold red in Table S4 .

Contingency-based statistical testing demonstrated a highly significant enrichment of pathway-level alterations among TP53-mutant tumors ( p ≈ 0), with a strong odds ratio indicating substantial overlap between mutation status and pathway activation.

Accordingly, an analysis of variance (ANOVA) for further investigating trauma-specific differences showed highly significant group differences at two hours, two and three weeks after trauma ( p = 0.000, 0.001 and 0.005).

The p -values associated with these differences were highly significant, with miR-17 ( p = 0.000), miR-191 ( p = 0.0001), let-7e ( p = 0.0001), and miR-33a ( p = 0.003).

As shown in Figure 1 A, one genome-wide highly significant associated position on BTA13 (ARS-BFGL-NGS-107931; position 63,500,701) was detected (−log 10 P -value = 167.56).

The Steiger analysis demonstrated highly significant directional associations for CEP68 using both blood ( p = 1.92 × 10 −137 ) and LAA ( p = 4.88 × 10 −49 ) eQTLs.

Statistical analysis showed that there was a strong and highly significant negative correlation between the rate of change in expression and chimeric frequency (Pearson: r = −0.556, p = 4.69 × 10 −119 ; Spearman: r = −0.601, p = 7.34 × 10 −144 ).

Repeated measures ANOVA showed a significant main effect of time and treatment, but only a slight tendency towards significance for time*treatment interaction (main effect of time: F(7.860,337.984) = 56.832, p = 1.88 × e −57 , ηp 2 = 0.569; main effect of treatment: F(4,43) = 5.973, p = 0.0006, ηp 2 = 0.357; time*treatment: F(31.440,337.984) = 1.396, p = 0.082, ηp 2 = 0.115).

In lung adenocarcinoma tissue, CHRNA5 showed a modest positive association with (AD: Z = 2.36, p = 0.018) but a highly significant negative association with lung cancer (LC: Z = −15.72, p = 1.17 × 10 −55 ).

Statistical significance was assessed against the two different control models using one-sided Mann–Whitney U tests, which yielded highly significant p -values ( p = 9.83 × 10 −55 and p = 4.94 × 10 −44 respectively).

MMP14 exhibited a marked increase in expression in tumor tissues, with a highly significant difference between normal and cancer groups ( p = 4.9 × 10 −45 ).

Coexpression of CD47 and IFT57 mRNAs Is Intrinsic to Cancer Cells A highly significant positive correlation was also observed between CD47 and IFT57 mRNA expression across the 1156 cell lines in the Cancer Cell Line Encyclopedia (CCLE) [ 26 ] ( p = 4.6 × 10 −36 , Table 1 , Figure 1 d).

The results showed pathways involved in repairing damaged nucleotides/DNA as highly significant in determining alkylating agent sensitivity: the Fanconi anemia pathway, ( p = 1.04 × 10 −35 ), homologous recombination (2.00 × 10 −24 ), nucleotide excision repair (2.77 × 10 −9 ), and non-homologous end-joining (1.04 × 10 −7 ) ( Figure 6 ). 3.

However, only for HNF1β (HNF1B_MOUSE.H11MO.0.A, [ 14 ]) we found the extremely significant asymmetry within predicted CEs toward the partner motif ( p < 2 × 10 −28 and p < 4 × 10 −17 for CEs with an overlap of motifs and with a spacer, respectively).

The type of incubation fluid exhibits a highly significant impact on the sorption ability, as indicated by an exceptionally low p -value ( p = 2.45 × 10 −28 ), suggesting that the fluid type strongly influences the swelling behavior of hydrogels.

Two-by-two χ 2 tests comparing each mutant to ndt80 Δ at the same threshold confirmed that all contrasts were highly significant (χ 2 = 86.7–197.2, df = 1, p < 10 −20 ; full statistics in Table S2 ).

The difference between the two groups was highly significant by the χ 2 test (χ 2 = 76.0603, p = 3.01 × 10 −18 ).

Protein–protein interaction (PPI) analysis revealed a highly significant network connectivity among these proteins ( p < 1.0 × 10 −16 ).

By enhancing the confidence levels of the PPI to the highest level (0.9), the number of edges decreased to 2534 and the node degree average to 8.11, but the PPI enrichment remained highly significant ( p < 1.0 × 10 −16 ), underscoring the quality of the proteomic data.

It further confirmed that the association of clock PRRs with flowering control genes was not random and connected with a highly significant value of p < 1 × 10 −16 .

The network demonstrated highly significant connectivity (PPI enrichment p -value < 1 × 10 −16 ), as 201 interactions were observed compared to the 27 edges expected by chance, supporting functional relationships among the proteins rather than random connectivity.

However, the effects were clearly non-random, with highly significant enrichments of specific pathways and an overall protein–protein-interaction enrichment p -value of <1.0 × 10 −16 upon bioinformatics analysis at the STRING (search tool for the retrieval of interacting genes) webpage in Heidelberg.

Similarly, aphid counts and damage scores also showed a highly significant difference ( p -value = 2 × 10 −16 and 3.59 × 10 −14 ) ( Figure 6 C).

The difference was highly significant ( p < 2.2 × 10 −16 ), indicating robust epigenetic dysregulation of the SYTL4 locus in breast cancer ( Figure 2 A).

This reduction was highly significant with a p -value < 2.2 × 10 −16 ( Figure 2 ).