There was a significant trend with trial commencement year for the measures physical activity ( p = 0.002) and weight/BMI ( p = 0.000) and all symptoms, except for appetite loss ( p = 0.115) and pain ( p = 0.433).
Excerpts
The model demonstrated moderate discrimination with a concordance index of 0.667, and the overall likelihood-ratio test was highly significant (χ 2 = 19.4, p = 0.002). 3.8.
The survival data frequency distribution analysis, upon crossing the clusters by the overall survival results and the age groups, gave an extremely significant result in the mid-age population ( p = 0.002).
When considering the overall miRNA expression ( miRNA Sum ), the difference between healthy controls and ccRCC patients remained highly significant (U = 452.5, Z = −3.157, p = 0.002), confirming a distinct urinary miRNA signature associated with ccRCC ( Table 2 ).
Both pCEA and pCA 19-9 markers demonstrated highly significant discriminatory ability (respectively, p -value = 0.002 and p < 0.001).
A PERMANOVA to test for overall differences among the groups yielded highly significant results ( p = 0.002).
A highly significant increase ( p = 0.0027, Welch’s two sample t -test) in the length of actin microfilaments was detected with a reduction in the cell thickness ( p = 0.0162, Welch’s two sample t -test) of MCF7 cells that induced K16 compared to control cells ( Figure 3 H,I).
Age at diagnosis was the only variable with a nominally significant association with OS (HR = 1.03, 95% CI 1.01–1.04, p = 0.003; FDR = 0.057).
Paudyal et al.’s HNC study results exhibited an increasing trend in ADC at each intra-treatment week when compared with pretreatment in the complete response group ( p < 0.003) who received CRT [ 20 ].
Nominally significant adverse associations were observed in eight strata on unadjusted testing: an age below the cohort median of 72 years (HR 2.08, 95% CI 1.28–3.38; p = 0.003), an age of 72 years or older (HR 1.98, 95% CI 1.33–2.96; p < 0.001), female sex (HR 2.21, 95% CI 1.18–4.16; p = 0.013), male sex (HR 1.91, 95%
Further Kaplan–Meier analysis stratified by tumour stage revealed a highly significant difference in survival based on tumour size (log-rank p = 0.003), with patients having tumours > 4 cm experiencing markedly poorer survival, particularly in Stage III–IV disease, where their median survival was only 26 months, compared to those with tumours ≤ 4 cm, whose median survival was not reached.
Overnight co-culture with progesterone (24 h) induced a highly significant reduction in NK cell cytotoxicity of tumor targets at differing concentrations (10 μM vs. 0.1 μM progesterone; n = 13; p = 0.0038; Figure 1 f).
Results: Dermoscopy showed a nominally significant shift toward smaller vessel diameter categories after therapy (ATS = 8.183, df = 1, p = 0.004).
The multiple logistic regression showed a highly significant ( p = 0.004) influence of SUVmax on the occurrence of distant metastasis.
NR; HR 2.97, 95% CI 1.35–6.52; p < 0.005); this association remained highly significant in a multivariable analysis (HR 3.3; 95% CI 1.5–7.3; p = 0.004) [ 91 ].
HCC patient race exhibited a significant trend (chi-square test, p = 0.004), as shown in Figure 6 E, where a higher proportion of SR+ and SR- HCC tumors were found in white and Asian patients, respectively.
Furthermore, a highly significant negative correlation between CD15s-12 levels and the extent of the primary gastric tumor (T2a and T2b) ( p = 0.004/τ = 0.360) was evidenced ( Figure 5 B).
In particular, with the exclusion of studies with salivary tubes applied in less than 20% of cases, heterogeneity (I 2 = 57%) could be improved, reaching finally a highly significant result for the meta-analysis (OR 0.42; 95% CI 0.23–0.78; p = 0.005).
Differences were defined as ‘not significant’ in cases with p -values > 0.1, as ‘tendentially significant’ (significant *) with p -values between 0.1 and 0.05, as ‘significant’ (significant **) with p -values between 0.05 and 0.005 and as ‘highly significant’ (significant ***) with p -values < 0.005.
Pooling the unirradiated and 2 Gy-irradiated data indicated a highly significant TRAM-34-mediated depolarization of the membrane potential in K Ca 3.1 WT ( p = 0.005, n = 2 tests) but not in in the pooled K Ca 3.1 KO cells ( p = 0.8, n = 2 tests, data not shown).
A categorization by surgical resection of liver metastases demonstrated a highly significant difference ( p = 0.005) in OS between those patients who underwent surgical resection (median OS 32.8 months; 95% CI, 21.42–44.18; n = 11) and those who did not (median OS 12.20 months; 95% CI; 5.58–18.82, n = 31) ( Figure 3 A).
A p -value > 0.05 indicated that the data followed a normal distribution and justified the use of t -tests: Differences were considered as “highly significant” in cases with p -values ≤ 0.005, as “significant” with p -values ≤ 0.05, and as “borderline significant” with p -values between 0.05 and 0.10.
As shown in Table 4 , although the strength of linear correlation between SphK1 and GLUT-1 was weak, it was statistically extremely significant for all osteosarcomas ( p = 0.005 for percentage of stained cells and p = 0.001 for IRS score).
Notably, this expression is even further enhanced when cells are treated with sEVs from patients at T3, displaying a highly significant increase compared to the control ( p < 0.005).
In contrast, Toca 511-transduced subcutaneous tumors treated with 5-FC showed highly significant growth inhibition compared to PBS-treated controls ( p = 0.0051 in A549 model ( Figure 4 A), p = 0.0018 in Ex-3LL model ( Figure 4 B).