PfSPZ-CVac efficacy against malaria increases from 0% to 75% when administered in the absence of erythrocyte stage parasitemia: A randomized, placebo-controlled trial with controlled human malaria infection.

For Group 3, the geometric mean PPD was highest after the first vaccination (1194 parasites/mL), declined after the second vaccination (426 parasites/mL), and was similar following the third (437 parasites/mL) vaccination; the Group 3 reduction in PPD after the second dose compared to the first dose was borderline significant (p = 0.056, paired Student’s t-test).

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Group 3 showed a trend toward progressive reductions in the density of transient parasitemia with successive immunizations, particularly from the first to the second, indicating possible effects of innate and/or early adaptive immunity.

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