extremely significantp -value ≤ 0.05
The expression difference level was defined using the following rules: log2fold change ≥ 0.5 or log2fold change ≤−0.5) and adjusted p -value ≤ 0.01, extremely significant (**); log2fold change ≥ 0.5 or log2fold change ≤−0.5) and 0.01 < adjusted p -value ≤ 0.05, significant (*); otherwise, insignificant. 4.5.