Serum creatinine may indicate risk of symptomatic intracranial hemorrhage after intravenous tissue plasminogen activator (IV tPA).

Results did not reach statistical significance, but are similar to several small, previously published reports.

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We feel this is less likely, given that there was a definite trend toward eGFR being associated with higher risk of sICH, and that this trend was present for all definitions of renal impairment in our study (either by creatinine or eGFR).

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