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Increments and duplication events of enzymes and transcription factors influence metabolic and regulatory diversity in prokaryotes.

PLoS One · 2013 · PMC3726781 · PMID 23922780

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a negative trendno p-value reported
The rate of change (derivative) associated with the power-law behavior exhibits a negative trend for enzymes, while for TFs is positive.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.